Defining the cellular origin of chronic lymphocytic leukaemia

定义慢性淋巴细胞白血病的细胞起源

基本信息

批准号：
G0601099/1
负责人：
Alison Michie
金额：
$ 46.36万
依托单位：
University of Glasgow
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2007
资助国家：
英国
起止时间：
2007 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=G0601099%2F1
关键词：
Defining cellular origin chronic lymphocytic

项目摘要

Leukaemia is a cancer that results from a disruption in the normal development of cells within the blood. This disruption can occur when regulatory elements responsible for controlling white blood cell development malfunction. We recently discovered that a disturbance in the function of a ubiquitously expressed element protein kinase C during white blood cell development, initiates a specific type of leukaemia, chronic lymphocytic leukaemia (CLL). CLL is the most common adult blood cancer in the Western world, for which there is currently no cure. While many research groups are engaged in investigating the mechanisms that can induce CLL cell death in patients as a mechanism to remove the leukaemic cells, little is known about the origin of CLL cells. Until now it has been almost impossible to address this question, as the factors responsible for this initiating this leukaemia have remained elusive. However, our novel mouse model provides us with a unique opportunity to gain fundamental knowledge about the cellular origin of CLL, and may assist in the generation of novel treatments to cure CLL. Within our university-based research laboratory, we will perform established cellular and molecular techniques to identify which cell is responsible initiating CLL. In parallel with these experiments, we will characterise the CLL-initiating cells in CLL-patient cell samples. In this way, we will uncover important information regarding the cell of origin for CLL.

白血病是一种因血液内细胞正常发育受到破坏而导致的癌症。当负责控制白细胞发育的调节元件发生故障时，就会发生这种破坏。我们最近发现，白细胞发育过程中普遍表达的蛋白激酶 C 元件的功能紊乱会引发一种特定类型的白血病，即慢性淋巴细胞白血病 (CLL)。 CLL 是西方世界最常见的成人血癌，目前尚无治愈方法。虽然许多研究小组正在研究诱导患者 CLL 细胞死亡的机制，作为清除白血病细胞的机制，但人们对 CLL 细胞的起源知之甚少。到目前为止，解决这个问题几乎是不可能的，因为引发这种白血病的因素仍然难以捉摸。然而，我们的新型小鼠模型为我们提供了获得有关 CLL 细胞起源的基础知识的独特机会，并可能有助于开发治疗 CLL 的新疗法。在我们大学的研究实验室内，我们将执行已建立的细胞和分子技术来确定哪个细胞负责引发 CLL。与这些实验并行，我们将表征 CLL 患者细胞样本中的 CLL 起始细胞。通过这种方式，我们将揭示有关 CLL 起源细胞的重要信息。