Mechanisms of Virus Replication and Gene Expression

病毒复制和基因表达机制

• 批准号: 7692634
• 负责人: Anne Elizabeth Simon
• 金额: $ 17.35万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7692634
• 关键词: Gene Expression; Virus Replication

DESCRIPTION (provided by applicant): Research in Virology requires more than a focused understanding of human pathogens. It requires comprehensive knowledge of viruses that infect hosts ranging from simple eukaryotes to complex multicellular organisms. A more comprehensive understanding of the breadth of Virology promises to provide the tools needed to control perplexing and devastating diseases in humans, as well as animals and plants. Substantive steps in knowledge acquisition require programs that prepare students to synthesize data from diverse systems, including model systems. The systems studied by University of Maryland Virology Program members include such important human pathogens as HIV, influenza, papillomavirus, poxvirus. West Nile, caliciviruses, as well as prions, viroids, fungal hypoviruses, and the model plant viruses Tobacco mosaic virus and Turnip crinkle virus. At the core of our training program are 14 well-funded investigators recognized as leaders in their fields from the Department of Cell Biology and Molecular Genetics, Maryland-Virginia Regional Vet Medicine, University of Maryland Biotechnology Institute Center for Biosystems Research, NIH, NCI, and USDA. Our faculty bring an extraordinarily broad range of expertise, from cellular and molecular biology to genomics and evolution, and from biochemistry to nanotechnology and vaccine development Trainees progress through innovative rotations, advanced courses in molecular and cellular biology, signal transduction, virology, and pathogenesis, journal clubs, attend monthly group meetings and a yearly retreat This training, along with state-of-the-art research projects, prepare trainees for careers centered on combating current and emerging viruses that threaten human health. This renewal application requests financial support for five graduate student traineeships. By combining this support with funds available through grants and intramural funds, over 20 pre-doctoral students will be trained in a five year period. The requested support will focus on attracting incoming students and students in their final years. We are committed to offering this exceptional training experience to highly-motivated students, with a special outreach to minorities, who will greatly enrich the potential for a global public health impact. RELEVANCE: Viruses infect nearly all life forms, are responsible for some human cancers, and are devastative disease agents that can cause world-wide pandemics. When properly harnessed, viruses can also be powerful research tools for dissecting cellular processes. This training proposal seeks continued support for training virologists prepared to meet research challenges common to all viruses- which include developing strategies to protect humans, animals, and plants from viral diseases to improve the quality of people's lives.

描述（由申请人提供）：病毒学研究不仅需要集中理解人类病原体。它需要对感染宿主的病毒的全面知识，从简单的真核生物到复杂的多细胞生物。对病毒学广度的更全面的理解有望提供控制人类以及动物和植物的困惑和破坏性疾病所需的工具。知识获取的实质性步骤需要使学生准备从包括模型系统在内的不同系统中综合数据的程序。马里兰州病毒学计划成员研究的系统包括重要的人类病原体，例如艾滋病毒，流感，乳头瘤病毒，波病。西尼罗河，彩毛病毒以及prions，病毒，真菌下病毒以及模型植物病毒烟草病毒和萝卜皱纹病毒。我们培训计划的核心是14位资金资助的调查人员，他们在细胞生物学和分子遗传学系，马里兰州 - 维吉尼亚地区兽医医学，马里兰州生物技术研究所中心研究中心，NIH，NCI，NCI和USDA。我们的教师带来了广泛的专业知识，从细胞和分子生物学到基因组学和进化，从生物化学到纳米技术到纳米技术和疫苗开发人员通过创新的轮换，分子和细胞生物学的先进课程，培训一定的小组，以及一度培训，以及一年的研究，以及培训，以及一年的培训，以及一年的培训。为受训者准备以抗击威胁人类健康的当前和新兴病毒的职业。该更新申请要求为五名研究生培训的财政支持。通过将此支持与通过赠款和壁内基金获得的资金相结合，将在五年内接受20多名博士前学生的培训。所要求的支持将集中在最后几年吸引新生的学生和学生。我们致力于向高度动机的学生提供这种出色的培训经验，并与少数民族进行了特别的宣传，他们将极大地丰富全球公共卫生影响的潜力。 相关性：病毒几乎感染了所有生命形式，是某些人类癌症的原因，并且是可能导致全球大流行病的破坏性疾病药物。如果得到适当的利用，病毒也可能是剖析细胞过程的强大研究工具。该培训建议寻求对准备应对所有病毒所常见的研究挑战的培训医生的持续支持 - 包括制定保护人类，动物和植物免受病毒疾病的策略，以改善人们生活的质量。