Alcohol Dependence: Pharmacotherapy, Pharmacogenetics, and Genetics

酒精依赖：药物治疗、药物遗传学和遗传学

• 批准号: 7789394
• 负责人: ALBERT JOSEPH ARIAS
• 金额: $ 18.35万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7789394
• 关键词: Acute; Alcohol dependence; Alcoholism; Alcohols; Anticonvulsants; Applications Grants; Arts; Award; Clinical; Clinical Research; Clinical Trials; Collaborations; Communication; Complement; Controlled Clinical Trials; Data; Development; Ethics; Funding; Genetic; Genomics; Goals; Health; Heavy Drinking; Human; Human Genetics; Intervention; Knowledge; Leadership; Learning; Manuscripts; Medical; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methods; Naltrexone; Patients; Pharmacogenetics; Pharmacotherapy; Pilot Projects; Placebo Control; Placebos; Population; Preparation; Public Health; Randomized; Research; Research Personnel; Research Proposals; Scientist; Sertraline; Staging; Statistical Methods; Supervision; Training; Translating; Treatment outcome; United States; Work; alcohol abuse therapy; alcohol research; alcohol response; alcohol use disorder; alcoholism therapy; career; career development; design; drinking; effective therapy; experience; improved; novel; patient oriented research; programs; public health relevance; skill acquisition; skills; statistics; topiramate; treatment trial

DESCRIPTION (provided by applicant): In view of the growing demand for new and more effective treatments for alcohol use disorders (AUDs), which are highly prevalent in the population, a need exists for investigators with expertise in the conduct of alcohol treatment research.. There is also a need for researchers who are conversant with human genetics and in particular, pharmacogenetics, to translate these rapidly evolving fields into meaningful advances in the treatment of patients with AUDs. I propose a four-year plan of mentored patient-oriented research (POR) at the the NIAAA-funded Alcohol Research Center at the Univ. of CT Health Center under the supervision and mentorship of Dr. Henry Kranzler. The plan includes completion of substantial coursework and mentoring in applied statistics, with an emphasis on the application of pharmacogenetics to both the acute response to alcohol and the treatment of alcohol dependence. I will also complete coursework in translational genomics to assist me in achieving my main goal of developing an independent program of research on the application of pharmacogenetics to clinical trials for alcohol dependence by the end of the four-year career award period. I will complete a 12-week randomized, placebo-controlled clinical trial of the novel anticonvulsant zonisamide in 40 alcohol dependent subjects, which will provide me with pilot data for additional research proposals. I will also continue my work in ongoing trials and human alcohol challenge studies, all of which include pharmacogenetic components. The acquisition of new skills will be achieved through formal coursework (including the ethical conduct of research) and continued collaboration with established investigators and the ongoing receipt of mentoring in clinical trials and pharmacogenetics (to enable me to apply the skills learned in the classroom in the context of ongoing clinical research). I will also continue to develop my skills in grantsmanship, manuscript preparation, effective communication, academic collaboration, and leadership. This revised application contains substantial revisions resulting in well-focused career development and research plans, and explication of the need for further training. Receipt of this award is key to my continued development as a clinical alcohol researcher. PUBLIC HEALTH RELEVANCE: This research will focus on improving medical treatments for alcoholism, a condition that continues to be prevalent in the United States, and is a major public health concern. This research will provide for the training and development of a medical scientist who will specialize in developing state of the art medical interventions to improve treatment and outcomes for patients with alcoholism.

描述（由申请人提供）：鉴于对人群中高度普遍的新型和更有效治疗的对饮酒障碍的新需求不断增长，因此对具有专业知识的研究饮酒研究的研究人员存在需求。.还需要对人类遗传学的研究人员，尤其是对患者进行培训的培训，以使这些快速的培养型领域的培训率提高了这些方法，以实现这些快速培训，以实现这些范围，以实现这些疗程，以实现良好的影响力。我建议在大学的NIAAA资助的酒精研究中心进行四年计划的注重患者研究（POR）。在亨利·克兰兹勒博士的监督和指导下，CT卫生中心的工作。该计划包括在应用统计数据中完成实质性的课程和指导，重点是将药物遗传学应用于对酒精的急性反应和酒精依赖的治疗。我还将完成转化基因组学的课程工作，以帮助我实现我的主要目标，即在四年制职业奖项期结束之前制定有关药物遗传学在酒精依赖临床试验中应用的独立研究计划。我将在40名酒精依赖受试者中完成一项为期12周的随机，安慰剂对照的临床试验，这将为我提供其他研究建议。我还将继续进行正在进行的试验和人类酒精挑战研究，所有这些都包括药物遗传学成分。获得新技能的获取将通过正式课程（包括研究的道德行为）来实现，并继续与已建立的研究人员合作，并在临床试验和药物遗传学中持续收到指导（使我能够在持续临床研究的背景下运用课堂上学到的技能）。我还将继续发展我在赠款，手稿准备，有效的沟通，学术合作和领导力方面的技能。该修订的应用程序包含大量修订，导致了专注的职业发展和研究计划，并阐明了进一步培训的需求。收到该奖项是我作为临床酒精研究人员持续发展的关键。 公共卫生相关性：这项研究将着重于改善酒精中毒的医疗治疗，这种疾病在美国仍然很普遍，这是一个主要的公共卫生问题。这项研究将为医学科学家的培训和开发提供，他们将专门发展最先进的医疗干预措施，以改善酒精中毒患者的治疗和结果。