Patient Oriented Research in Transplant and Oncology ID

移植和肿瘤学 ID 领域以患者为导向的研究

• 批准号: 7988983
• 负责人: Kieren A. Marr
• 金额: $ 19.9万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7988983
• 关键词: Academic Training; Address; Algorithms; Antifungal Agents; Area; Aspergillosis; Aspergillus; Aspergillus fumigatus; Award; Biological; Biology; Cancer Patient; Candidiasis; Caring; Cessation of life; Clinical; Clinical Data; Clinical Research; Clinical Trials; Clostridium difficile; Cohort Studies; Combined Modality Therapy; Communicable Diseases; Computerized Medical Record; Cystic Fibrosis; Data; Databases; Development; Diagnostic; Diagnostic tests; Diarrhea; Disease; Education; Educational Curriculum; Educational process of instructing; Elements; Epidemiology; Exhibits; Faculty; Future; Goals; Grant; Growth; Immune; Industry; Infection; Infection Control; Intervention; Laboratory Study; Leadership; Measures; Mentors; Mentorship; Morbidity - disease rate; Mycoses; Natural Immunity; Organ Transplantation; Outcome; Patients; Performance; Population; Predisposition; Prevention; Prevention and Treatment of Opportunistic Infection; Prevention therapy; Records; Relapse; Research; Research Infrastructure; Research Support; Resources; Scientist; Solid; Source; Structure; Supportive care; Therapeutic; Time; Training; Training Programs; Translational Research; Transplant Recipients; Transplantation; United States National Institutes of Health; Universities; cancer care; career; cohort; cystic fibrosis patients; cytotoxic; design; graduate student; high risk; infectious disease treatment; macrophage; medical schools; multidisciplinary; next generation; oncology; patient oriented research; patient population; programs; public health relevance; reconstitution; therapy duration; translational study; treatment strategy; trend

DESCRIPTION (provided by applicant): This is a proposal for a K24 Mid-career award in Patient-oriented research (POR) for Kieren A. Marr MD, of the Johns Hopkins University (JHU) School of Medicine. Dr. Marr recently became the Director of the Transplant and Oncology Infectious Diseases Program in the Division of Infectious Diseases at JHU. The award supports the large goal of enabling leadership of this newly developed academic Transplant and Oncology ID program, with immediate goals of building an infrastructure to allow for structured teaching and research on infectious complications and initiating new directions of institutional research. The principal aims are to: 1. Develop a comprehensive academic training program for clinical and translational research in Transplant and Oncology Infectious Diseases; and 2. Define trends in epidemiology and ID outcomes by performing a prospectively maintained dynamic cohort study and building a database that combines elements from transplant and oncology databases, infection control records, and electronic medical records. As part of aim 2, new projects will be established to define the epidemiology and outcomes of Clostridium difficile infection in oncology patients, and to define infectious complications in high-risk recipients of solid organ transplants. These aims will be addressed in the context of providing mentorship to new and existing junior faculty, and to fellows and graduate students. The K24 will allow for Dr. Marr to more effectively pursue her long-term career goals of developing a "world-class" academic program at Johns Hopkins that specializes in the unique ID care of transplant and oncology patients, and building a multidisciplinary translational clinical research program focused on prevention and treatment of opportunistic infections. Public Health Relevance Statement: This is a proposal for a Mid-career award in patient research for Kieren A. Marr, MD, of the Johns Hopkins University (JHU) School of Medicine. Dr. Marr recently became the Director of the Transplant and Oncology Infectious Diseases Program in the Division of Infectious Diseases at JHU. The award supports the goal of developing a "world-class" academic program at Johns Hopkins that specializes in the care of organ transplant and cancer patients, and building a research program focused on prevention and treatment of infectious diseases.

描述（由申请人提供）：这是约翰·霍普金斯大学（JHU）医学院的Kieren A. Marr MD授予K24中期研究（POR）的K24中期奖的建议。 Marr博士最近成为JHU传染病部门的移植和肿瘤学传染病计划的主任。该奖项支持实现这一新开发的学术移植和肿瘤学ID计划的领导能力的重大目标，其直接的目标是建立基础设施，以允许有关传染性并发​​症的结构化教学和研究，并启动机构研究的新方向。主要目的是：1。针对移植和肿瘤学传染病的临床和转化研究制定全面的学术培训计划； 2。通过进行前瞻性维护的动态队列研究和构建数据库来定义流行病学和ID结果的趋势，该数据库结合了移植和肿瘤学数据库，感染控制记录和电子病历的元素。作为AIM 2的一部分，将建立新项目，以定义肿瘤学患者艰难梭菌感染的流行病学和结果，并定义固体器官移植的高风险受体的感染并发症。这些目标将在为新的和现有的初级教师以及研究员和研究生提供指导的背景下解决。 K24将允许Marr博士在约翰·霍普金斯（Johns Hopkins）制定“世界一流”学术计划的长期职业目标，专门研究移植和肿瘤患者的独特ID护理，并建立一项多学科转化临床研究计划，专注于预防和治疗机会感染。 公共卫生相关性声明：这是约翰·霍普金斯大学（JHU）医学院的Kieren A. Marr医学博士的患者研究中期奖的提案。 Marr博士最近成为JHU传染病部门的移植和肿瘤学传染病计划的主任。该奖项支持在约翰·霍普金斯（Johns Hopkins）制定“世界一流”学术计划的目标，该计划专门研究器官移植和癌症患者，并建立着针对预防和治疗传染病的研究计划。