Development of A Lab-on-a-Chip System for Saliva-Based Diagnostics
开发基于唾液的诊断芯片实验室系统
基本信息
- 批准号:7282487
- 负责人:
- 金额:$ 133.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-09-01 至 2010-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAgreementAnusAreaArtsBacillus (bacterium)Biological AssayBiological MarkersBiosensorBuffersC-reactive proteinCD40 LigandCardiacCardiovascular systemCellsCharacteristicsChemicalsChemistryChronicClassClinicalCommunicationComplexComputer softwareConditionCoronary ArteriosclerosisCytometryDataData AnalysesDetectionDevelopmentDevicesDiagnosisDiagnosticDiagnostic testsDiseaseDoctor of MedicineDoseEdentulous MouthElectrodesElectronicsElementsEngineeringEnzyme-Linked Immunosorbent AssayEquipmentEventFingerprintFluorescenceFoundationsFundingFutureGeneral HospitalsGenerationsGlassGoalsGoldHIVHandHealth StatusHealthcareHumanImmunoassayIndividualIndustryInflammationInflammatoryInjection of therapeutic agentInterleukin-6InvasiveJointsLaboratoriesLiquid substanceMarriageMassachusettsMeasurementMeasuresMethodologyMethodsMetricMicrofabricationMicrofluidic MicrochipsMicrofluidicsMissionMoldsMonitorNanotechnologyNeutrophil CollagenaseNone or Not ApplicableOperative Surgical ProceduresOpticsOralOral healthParotid GlandPatientsPatternPerformancePeriodontal DiseasesPeriodontitisPhysiologicalPlasticsPolymerase Chain ReactionPolymersPrincipal InvestigatorProceduresProcessProteinsProteomicsRangeRecoveryReportingReproduction sporesResearchResearch InfrastructureResearch PersonnelResourcesRiskRisk AssessmentSalivaSalivarySamplingScienceSeriesSerumSourceStagingStandards of Weights and MeasuresStructureSystemSystemic diseaseSystems AnalysisTechnologyTestingTexasThromboplastinTimeTranslatingTreatment outcomeTumor Necrosis Factor-alphaTumor Necrosis FactorsTumor necrosis factor receptor 11bUnited States Food and Drug AdministrationUnited States National Institutes of HealthUniversitiesValidationWalkersWireless TechnologyWorkaustinbasebiochipconceptdata acquisitiondesignhuman TNF proteinhuman diseaseimmune functioninstrumentinstrumentationlensmedical schoolsmicro-total analysis systemminiaturizeoral fluid diagnosticpoint of carepre-clinicalprogramsprototypereal world applicationresponsesaliva diagnosticsalivary diagnosticssensorsuccesstool
项目摘要
DESCRIPTION (provided by applicant): Saliva is an important diagnostic fluid that has the potential to be used for detection of essential biomarkers for both oral and systemic diseases. Unfortunately, the current lack of reliable detection methods for measurement of important analytes within this complex biomatrix has hindered progress in salivary diagnostics. To help remove this barrier, recent promising activities have been initiated in microfluidic-based Lab-on-a-Chip (LOC) systems. While several miniaturized platforms are being developed now, few of these systems have evolved to the point where important protein biomarkers can be measured over the physiological range using real saliva samples. Towards this essential goal, the team of investigators from UT and UK have developed and documented carefully an integrated biochip assay system that is suitable for measurement of panels of important inflammatory markers (e.g. CRP, IL-1beta, MMP-8, TNF-alpha, IL-6) in saliva. This newly fashioned ultra-sensitive method has been used to extend saliva-based diagnostics to the low levels of CRP found in saliva, therefore allowing for the first comparison of CRP levels between healthy, periodontitis, and edentulous patients. The miniaturized system correlates nicely with established macroscopic "gold standard" methods. Thus, it now important to take the next steps to combine these functional components and associated methodologies so as to create a flexible platform system that may be used to promote and expand the field of salivary diagnostics. This U01 renewal program targets the development of portable devices that can be used to complete salivary diagnostic tests. The program will evolve with important biochip, analyzer and immunoassay development milestones to be completed in the first two years of the program. In year 1, integrated biochips and analyzers will be developed and tested. These alpha prototypes will be used to define specifications for more final systems. In year 2, fully developed biochips and analyzer suitable to serve, as beta prototypes will be fashioned. These highly functional portable systems will be used in years 3-5 to complete pre-clinical testing and validation. Salivary biomarker fingerprints that our team has already defined will be used to 1) discriminate stages of periodontitis and 2) identify risk for future cardiac events in coronary artery disease patients. Final data acquisition and FDA approval will be completed by year 5.
描述(由申请人提供):唾液是一种重要的诊断液体,有潜力用于检测口腔和全身疾病的基本生物标志物。不幸的是,目前缺乏可靠的检测方法来测量这种复杂生物基质中的重要分析物,阻碍了唾液诊断的进展。为了帮助消除这一障碍,最近在基于微流体的芯片实验室 (LOC) 系统中开展了一些有前途的活动。虽然现在正在开发一些小型化平台,但这些系统中很少有发展到可以使用真实唾液样本在生理范围内测量重要蛋白质生物标志物的程度。为了实现这一基本目标,来自 UT 和英国的研究团队开发并仔细记录了一个集成生物芯片检测系统,该系统适用于测量重要炎症标记物(例如 CRP、IL-1beta、MMP-8、TNF-α、 IL-6)在唾液中。这种新型超灵敏方法已用于将基于唾液的诊断扩展到唾液中发现的低水平 CRP,因此可以首次比较健康患者、牙周炎患者和无牙颌患者之间的 CRP 水平。小型化系统与已建立的宏观“金标准”方法很好地相关。因此,现在重要的是采取下一步措施将这些功能组件和相关方法结合起来,以创建一个可用于促进和扩展唾液诊断领域的灵活平台系统。 U01更新计划的目标是开发可用于完成唾液诊断测试的便携式设备。该计划将随着重要的生物芯片、分析仪和免疫测定开发里程碑的发展而发展,这些里程碑将在该计划的前两年内完成。第一年,将开发和测试集成生物芯片和分析仪。这些阿尔法原型将用于定义更多最终系统的规范。第二年,将开发出适合使用的完全开发的生物芯片和分析仪,作为测试原型将被制作出来。这些功能强大的便携式系统将在 3-5 年内使用,以完成临床前测试和验证。我们团队已经定义的唾液生物标记指纹将用于 1) 区分牙周炎的阶段,2) 识别冠状动脉疾病患者未来发生心脏事件的风险。最终数据采集和 FDA 批准将于第 5 年完成。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOHN T MCDEVITT其他文献
JOHN T MCDEVITT的其他文献
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{{ truncateString('JOHN T MCDEVITT', 18)}}的其他基金
Oral Dysplasia and Oral Cavity Cancer Risk in Dental and Medical Surveillance Settings Using a Chairside Chip-Based Cytopathology Tool
使用基于椅旁芯片的细胞病理学工具评估牙科和医疗监测环境中的口腔发育不良和口腔癌风险
- 批准号:
10605157 - 财政年份:2022
- 资助金额:
$ 133.42万 - 项目类别:
Oral Dysplasia and Oral Cavity Cancer Risk in Dental and Medical Surveillance Settings Using a Chairside Chip-Based Cytopathology Tool
使用基于椅旁芯片的细胞病理学工具评估牙科和医疗监测环境中的口腔发育不良和口腔癌风险
- 批准号:
10344966 - 财政年份:2022
- 资助金额:
$ 133.42万 - 项目类别:
Lab-on-a-Chip-Based System for Detection and Monitoring of Oral Cancer in Dental Settings
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- 批准号:
9387924 - 财政年份:2016
- 资助金额:
$ 133.42万 - 项目类别:
Lab-on-a-Chip-Based System for Detection and Monitoring of Oral Cancer in Dental Settings
用于牙科环境中口腔癌检测和监测的基于芯片实验室的系统
- 批准号:
9047158 - 财政年份:2016
- 资助金额:
$ 133.42万 - 项目类别:
Monitoring of Oral Cancer Patients Using Novel Lab-on-a-Chip Ensembles
使用新型芯片实验室整体监测口腔癌患者
- 批准号:
8299835 - 财政年份:2009
- 资助金额:
$ 133.42万 - 项目类别:
Monitoring of Oral Cancer Patients Using Novel Lab-on-a-Chip Ensembles
使用新型芯片实验室整体监测口腔癌患者
- 批准号:
7854787 - 财政年份:2009
- 资助金额:
$ 133.42万 - 项目类别:
Monitoring of Oral Cancer Patients Using Novel Lab-on-a-Chip Ensembles
使用新型芯片实验室整体监测口腔癌患者
- 批准号:
8521443 - 财政年份:2009
- 资助金额:
$ 133.42万 - 项目类别:
Monitoring of Oral Cancer Patients Using Novel Lab-on-a-Chip Ensembles
使用新型芯片实验室整体监测口腔癌患者
- 批准号:
7939647 - 财政年份:2009
- 资助金额:
$ 133.42万 - 项目类别:
Development of A Lab-on-a-Chip System for Saliva-Based Diagnostics
开发基于唾液的诊断芯片实验室系统
- 批准号:
7919019 - 财政年份:2006
- 资助金额:
$ 133.42万 - 项目类别:
Development of A Lab-on-a-Chip System for Saliva-Based Diagnostics
开发基于唾液的诊断芯片实验室系统
- 批准号:
7675356 - 财政年份:2006
- 资助金额:
$ 133.42万 - 项目类别:
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