Training: Hematology, Immunology & Stem Cell Biology

培训：血液学、免疫学

• 批准号: 7940840
• 负责人: Frans A. Kuypers
• 金额: $ 18.06万
• 依托单位: CHILDREN'S HOSPITAL & RES CTR AT OAKLAND
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7940840
• 关键词: Hematology; Immunology; Training; stem cell biology

DESCRIPTION (provided by applicant): This is the second resubmission of a competitive renewal application for a post-doctoral hematology training program located at Children's Hospital Oakland Research Institute (CHORI). The program provides the opportunity for research training in hematology, immunology, genetics, hematopoietic stem cell biology, and transplantation with a focus on the application of these disciplines to the hemoglobinopathies. This application requests three trainees per year. The program will emphasize hands-on bench and clinical research work in the laboratory or clinical setting of an experienced, NIH-supported investigator. A committee will participate in the selection and evaluation of candidates, as well as in the laboratory assignment. Eligible trainees with PhD, MD/PhD or MD degrees will be recruited who have a strong background and interest in cell or molecular biology, genetics, biochemistry, transplantation biology or clinical research. At the beginning of the fellowship, each trainee will develop a research hypothesis and write a research proposal, which will be reviewed and approved by the directors and mentors. Trainees will participate in core curriculum activities, meet daily with mentors, and monthly with program directors. Trainees will complete didactic coursework in ethics and statistics, and have access to advance courses such as molecular biology and stem cell biology. Trainees will participate in weekly laboratory meetings, monthly journal clubs and weekly research seminars. Trainees will present their research at national scientific meetings, publish several manuscripts in peer-reviewed journals, and begin to seek extramural grant support during their second year. The research opportunities in areas funded by NIH at CHORI include: (1) clinical research in sickle cell anemia and thalassemia, (2) red cell membrane structure and function, (3) immunologic development and immune response to vaccines, (4) bioiron, molecular regulation of ferritin synthesis, and iron toxicity, (5) lipid mediated signal transduction in stem cell biology, (6) genetic polymorphisms contributing to disease severity, (7) cord blood stem cell biology, and (8) stem cell transplantation for patients with hemoglobinopathies. Upon completion, trainees will be prepared to continue to work in an academic setting in the field of hemoglobinopathies and become qualified, independent scientists.

描述（由申请人提供）： 这是位于奥克兰研究所（Chori）儿童医院（CHORI）的博士后血液学培训计划的竞争性更新申请的第二次重新提交。该计划为血液学，免疫学，遗传学，造血细胞生物学研究提供了机会，并重点是将这些学科应用于血红蛋白病。该申请每年要求三名学员。该计划将在经验丰富的，由NIH支持的研究人员的实验室或临床环境中强调实践板凳和临床研究工作。委员会将参加候选人以及实验室任务的选择和评估。将招募拥有博士学位，医学博士学位或MD学位的合格学员，他们对细胞或分子生物学，遗传学，生物化学，移植生物学或临床研究具有强烈的背景和兴趣。在奖学金开始时，每个学员将制定一个研究假设并撰写研究建议，该计划将由董事和导师审查和批准。学员将参加核心课程活动，每天与导师会面，并每月与计划主任。受训者将完成道德和统计学的教学课程，并可以访问分子生物学和干细胞生物学等提前课程。学员将参加每周实验室会议，每月期刊俱乐部和每周研究研讨会。学员将在国家科学会议上介绍他们的研究，在同行评审期刊上发表几本手稿，并在第二年开始寻求校外赠款支持。 NIH在Chori资助的领域的研究机会包括：（1）镰状细胞贫血和丘脑贫血的临床研究，（2）红细胞膜的结构和功能，（3）免疫发育和对疫苗的免疫反应，（4）生物铁，（4）分子调节的分子调节，对铁蛋白合成和铁的毒性，（5）固定型植物，（5）降级（5）降级（5）降级（5）降级液化，（5）降级液化，（5）液化液化液质质量，（5）降级液化质量质量质量（5）液化液化液质质量，（5）降级液化液质质质质质质量，（5）降级液化液质质质量，（5）液化液质质量液化液体质量质量（5）。造成疾病严重程度的多态性，（7）血红蛋白病患者的脐带血细胞生物学和（8）干细胞移植。完成后，学员将准备继续在血红蛋白病领域的学术环境中工作，并成为合格的独立科学家。