United Kingdom Trial of Radioiodine Intervention for Subclinical Hyperthyroidism

英国放射性碘干预治疗亚临床甲状腺功能亢进症的试验

• 批准号: G0500783/1
• 负责人: Simon Pearce
• 金额: $ 22.52万
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0500783%2F1
• 关键词: United; Kingdom; Trial; Radioiodine; Intervention

Subclinical hyperthyroidism (SH) is a state of mild thyroid gland overactivity, defined by measurement of thyroid hormones in the blood. It is quite common, affecting about 2% of elderly people. Rather like high blood cholesterol levels, most people have no symptoms of SH, but it is associated with an increased risk of vascular disease. The problem is that we don`t know whether treating SH is worthwhile, in terms of benefit to vascular disease rates and other problems.We will carry out a trial comparing radioiodine treatment of the thyroid gland overactivity to standard therapy for cardiac risk factors in patients with SH. We will follow people with SH for 5 years after the treatment to find out whether this improves the rate of vascular diseases and other problems. This trial will form the first randomised study of treatment for this condition and will inform healthcare decision making for about 200,000 elderly people each year in the UK.

亚临床甲状腺功能亢进症 (SH) 是一种甲状腺轻度过度活跃的状态，通过血液中甲状腺激素的测量来定义。它很常见，影响约2%的老年人。与高血液胆固醇水平类似，大多数人没有 SH 症状，但它与血管疾病风险增加有关。问题是我们不知道治疗 SH 是否值得，就对血管疾病发生率和其他问题的益处而言。我们将进行一项试验，将甲状腺过度活动的放射性碘治疗与患者心脏危险因素的标准治疗进行比较与SH。我们将在治疗后对 SH 患者进行为期 5 年的跟踪，以了解这是否可以改善血管疾病和其他问题的发生率。该试验将构成该疾病治疗的首个随机研究，并将为英国每年约 200,000 名老年人的医疗决策提供信息。