PERIODONTAL DISEASE DURING PREGNANCY IN HIV POSITIVE PREGNANT WOMEN

HIV 阳性孕妇怀孕期间的牙周病

• 批准号: 7961272
• 负责人: lydia m lopez
• 金额: $ 1.24万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-24 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7961272
• 关键词: Biological; Clinical; Computer Retrieval of Information on Scientific Projects Database; Development; Evaluation; Funding; Grant; HIV; HIV Seropositivity; Health; Health Status; Immune; Infant; Institution; Intervention; Lead; Opportunistic Infections; Oral cavity; Oral health; Periodontal Diseases; Population; Pregnancy; Pregnant Women; Premature Birth; Process; Puerto Rico; Research; Research Personnel; Resources; Source; United States National Institutes of Health; base; improved; medical examination; premature

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The clinical focus in an HIV+ pregnant women should be based in a comprehensive evaluation of her initial health state, performing a complete medical examination that may include oral cavity and their surroundings, focusing in the signs that will reflect opportunistic infections and an evaluation of the pregnant women immune status. The purpose of this proposal is to explore the association between oral health status and periodontal disease in HIV+ pregnant women and preterm deliveries and LBWB. The null hypothesis of the study is that there is no significant independent association between presence of periodontal disease and PLBW of the infant when the potential confounding factors are taken into consideration. If there is a true association, this will lead to the identification cellular and biological mechanisms involved in the process and to the development of educational and other interventions approaches aimed at improved oral health status of HIV+ pregnant women. The proposed two specific aims to accomplish the above objective are: 1) To evaluate the oral health and periodontal status of HIV+ pregnant women. 2) To determine the relationship between oral health status as periodontal disease and HIV+ and prematurity in this population.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 HIV+孕妇的临床重点应基于对其初始健康状况的综合评估，进行可能包括口腔及其周围环境的完整医学检查，重点关注反映机会性感染的体征以及对孕妇的评估女性的免疫状况。 本提案的目的是探讨 HIV+ 孕妇的口腔健康状况与牙周病以及早产和 LBWB 之间的关联。 该研究的零假设是，当考虑到潜在的混杂因素时，牙周病的存在与婴儿的 PLBW 之间不存在显着的独立关联。 如果存在真正的关联，这将导致识别该过程中涉及的细胞和生物机制，并开发旨在改善艾滋病毒+孕妇口腔健康状况的教育和其他干预措施。 为实现上述目标，提出的两个具体目标是： 1) 评估HIV阳性孕妇的口腔健康和牙周状况。 2) 确定该人群中牙周病等口腔健康状况与 HIV+ 和早产之间的关系。