Toxoplasma gondii attachment and invasion: architecture, assembly and recognition of microneme protein complexes

弓形虫附着和入侵：微线体蛋白复合物的结构、组装和识别

• 批准号: G0800038/1
• 负责人: Steve Matthews
• 金额: $ 79.58万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0800038%2F1
• 关键词: Toxoplasma; gondii; attachment; invasion; architecture

A parasite colonises and grows in a different organism and while it is not a benefit to the host, it can often cause disease. The protozoan parasite Toxoplasma gondii (T. gondii) is both a single-celled and animal-like organism. It is a major cause of congenital birth defects, as well as being often associated with immuno-compromised patients (e.g. AIDS) and an important veterinary pathogen. As one of the most common parasitic infections of man and animals, infecting more than 500 million people worldwide, T. gondii has a large socio-economic impact. Current treatments have toxic side effects with low efficacy and a vaccine has yet to be developed, therefore T. gondii represents a highly underestimated public health problem. We propose to study the mechanisms by which T. gondii are able colonise and invade hosts from the atomic standpoint, which will provide guidance for the rational design of drugs and vaccines.

寄生虫在不同的生物体中生长和生长，虽然这对宿主没有好处，但通常会引起疾病。原生动物寄生虫弓形虫弓形虫（T. gondii）是单细胞和类似动物的生物。它是先天性先天缺陷的主要原因，并且通常与免疫受损患者（例如艾滋病）和重要的兽医病原体有关。作为人和动物最常见的寄生虫感染之一，全世界感染了5亿多人，T。Gondii具有巨大的社会经济影响。当前的治疗方法具有低疗效的毒性副作用，尚未开发疫苗，因此，冈迪（T. gondii）代表了一个高度低估的公共卫生问题。我们建议研究T. gondii能够从原子观点定殖并侵入宿主的机制，这将为药物和疫苗的合理设计提供指导。