BREAST DENSITY BY DXA

通过 DXA 测定乳房密度

基本信息

批准号：
7960432
负责人：
GERTRAUD MASKARINEC
金额：
$ 1.42万
依托单位：
UNIVERSITY OF HAWAII AT MANOA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7960432
关键词：
16 year old Adolescent Adult Age Distribution Age-Years Asian Americans Biological Body Weight Breast Breast Cancer Risk Factor Caucasians Caucasoid Race Clinical Research Computer Retrieval of Information on Scientific Projects Database Daughter Development Dual-Energy X-Ray Absorptiometry Eligibility Determination Enrollment Female Adolescents Funding Genetic Gonadal Steroid Hormones Grant Hawaii Hormones Image Institution Internal Breast Prosthesis Life Malignant Neoplasms Mammographic Density Mammography Measures Methods Monitor Morbid Obesity Mothers Oral Contraceptives Pacific Island Americans Paralysed Pharmaceutical Preparations Radiation Recruitment Activity Research Research Infrastructure Research Personnel Resources Risk Roentgen Rays Scanning Selective Estrogen Receptor Modulators Source Staging United States National Institutes of Health Woman base breast density cancer risk girls malignant breast neoplasm statistics

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Increasing epidemiologic and experimental evidence provides compelling evidence that breast cancer risk is determined early in life. A method to monitor breast development and composition in young women and girls is currently not available because of the risk of X-ray based mammograms. Dual Energy X-ray Absorptiometry (DXA) has extremely low radiation and is commonly available. The underlying rationale of this project is that predictors of breast cancer risk may be observed during pubertal development in girls. The specific aims of this project among adult women and adolescent girls, who will be recruited as mothers and biological daughter, will be to: - Correlate breast density measured by DXA with mammographic density among adult women; - Compare the association of known breast cancer risk factors with breast density from DXA scans to their association with mammographic density; - Assess DXA breast density and Tanner stage of breast maturation among adolescent girls; - Relate DXA breast density to other observable measure of pubertal maturation; - Examine the relation between breast density measured by DXA in mothers and biological daughters Our hypotheses are as follows: 1. DXA imaging can provide a valid assessment of breast density in adult women and in young girls; 2. DXA assessed breast density is associated with indicators of pubertal maturation and with known breast cancer risk factors; and 3. Due to its strong genetic component, breast density obtained from the DXA scans is correlated between mothers and biological adolescent daughters. Women at least 40 years of age with biological daughters 10-16 years of age will be recruited from Kaiser Permanente Hawaii. Expected enrollment is 50 Caucasian and 50 Asian-American or Pacific Islander pairs. The eligibility criteria are: 1. Normal mammogram during recent 6 months for adult women; 2. Biological daughters willing to participate in Tanner staging; 3. No condition that would interfere with study participation (e.g. cancer, paralysis, morbid obesity, breast implants); 4. Mother and daughter not taking medications that may interfere with hormone levels: oral contraceptives, other sex hormones, SERMs; 5. Willing to obtain DXA scans. We will calculate summary statistics to describe the distribution of age, body weight, pubertal stages, DXA measures, and mammographic density.

该副本是利用众多研究子项目之一由NIH/NCRR资助的中心赠款提供的资源。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是对于中心，这不一定是调查员的机构。越来越多的流行病学和实验证据提供了令人信服的证据，表明乳腺癌的风险是生命早期确定的。由于X射线乳房X线照片的风险，目前尚无一种监测年轻妇女和女孩乳房发育和成分的方法。双能X射线吸收法（DXA）具有极低的辐射，并且通常可用。该项目的根本理由是，在女孩的青春期发育期间，可能会观察到乳腺癌风险的预测因素。成年妇女和青少年女孩的具体目的（将被招募为母亲和亲生女儿）将是： - 通过DXA测量的乳房密度与成年女性的乳房X线摄影密度相关； - 比较已知的乳腺癌危险因素与乳腺密度从DXA扫描与乳房X线摄影密度相关的关联； - 评估青春期女孩中乳房成熟的DXA乳房密度和制革阶段； - 将DXA乳房密度与其他可观察到的青春期成熟度相关联； - 检查母亲和生物女儿DXA测量的乳房密度之间的关系我们的假设如下：1。DXA成像可以对成年女性和年轻女孩的乳房密度进行有效评估； 2。DXA评估的乳房密度与青春期成熟的指标和已知的乳腺癌危险因素有关。 3。由于其强大的遗传成分，从DXA扫描获得的乳房密度与母亲和生物青少年女儿之间相关。至少40岁的生物女儿妇女将从夏威夷的Kaiser Permanente招募10-16岁的妇女。预期入学率是50名高加索人和50个亚裔美国人或太平洋岛民对。资格标准为：1。成年女性最近6个月的正常乳房X线照片； 2。愿意参加制革商演出的生物女儿； 3。没有任何会干扰研究参与的状况（例如癌症，麻痹，病态肥胖，乳房植入物）； 4。妈妈女儿不服用可能干扰激素水平的药物：口服避孕药，其他性激素，Serms； 5。愿意获得DXA扫描。我们将计算摘要统计数据，以描述年龄，体重，青春期阶段，DXA测量和乳房X线摄影密度的分布。