INNOVATIVE CELL-BASED URINALYSIS FOR PATIENT ADHERENCE

创新的基于细胞的尿液分析可提高患者的依从性

• 批准号: 7880436
• 负责人: RAMA P RAMANUJAM
• 金额: $ 97.7万
• 依托单位: SWAASTH, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7880436
• 关键词: Academic Medical Centers; Adherence; Adult; Alternative Medicine; Animal Model; Animals; Anti-Inflammatory Agents; Anti-inflammatory; Ascorbic Acid; Biological Assay; Body Fluids; Botanicals; Broccoli - dietary; Cells; Cities; Clinical; Clinical Research; Clinical Trials; Colon Carcinoma; Complement; Complementary and alternative medicine; Consumption; Cranberries; Cultured Cells; Degradation Pathway; Detection; Development; Diet; Elements; Evaluation; Excretory function; Flour; Foundations; Freeze Drying; Funding; Future; Garlic; Gene Expression; Gene Targeting; Genes; Genetic; Ginger; Goals; Health Professional; Health Sciences; Healthcare; Human; Human Volunteers; Image; In Vitro; Inflammation; Inhibitory Concentration 50; Intervention; Investigation; Lead; Luc Gene; Luciferases; Malignant Neoplasms; Measurement; Measures; Mediating; Methods; Modality; Molecular; Monitor; Mus; National Center for Complementary and Alternative Medicine; Nature; Ohio; Oklahoma; Oral; Outcome; Patients; Pharmaceutical Preparations; Phase; Phase I Clinical Trials; Placebo Effect; Placebos; Pomegranate; Principal Investigator; Process; Protocols documentation; Public Health; Randomized Clinical Trials; Raspberries; Reagent; Recruitment Activity; Research; Research Infrastructure; Safety; Sampling; Savings; Scientist; Screening procedure; Serum; Services; Signal Transduction; Site; Small Business Innovation Research Grant; Spectrophotometry; System; Tea; Techniques; Technology; Testing; Time; Tumeric; United States; Universities; University Hospitals; Urinalysis; Urine; Validation; Western Blotting; Wheat; base; cancer cell; capsule; commercialization; compliance behavior; design; dietary supplements; dosage; drug discovery; drug testing; feeding; follow-up; genetic element; gum mastic; high throughput screening; in vivo; innovation; luminescence; minimally invasive; new technology; pilot trial; programs; research study; tool

DESCRIPTION (provided by applicant): The scientific and commercial goal of this small business innovation research (SBIR-Phase II) proposal is to develop cell-based assays for the detection of biologically active complementary and alternative medicine (CAM) agents in body fluids. The proposed project builds on the foundation of a molecular assay designed and validated through a recent Phase I funding. The strategy of identifying CAM agents in body fluids by an in vitro bio-luminescence imaging system complements another drug-discovery technology developed at Swaasth Inc, referred to as Genetic Expression and Measurement (GEMTM). Together, these cell-based CAM agent detection technologies will enable the development of novel technologies in monitoring objective measures of adherence to study-protocol in the investigations of CAM modalities. Swaasth Inc. has successfully developed molecular reagents and high throughput-screening infrastructure required to identify CAM agents. It is anticipated that the availability of GEM system will make effective use of the Phase II funding to further expand the detection of a variety of CAM agents and enhance minimally invasive patient adherence measurements for CAM modalities in clinical settings.

描述（由申请人提供）：这项小型企业创新研究的科学和商业目标（SBIR-CHASE II）提案是开发基于细胞的测定法，以检测体液中生物活性活性互补和替代药物（CAM）剂。拟议的项目建立在通过最近的I阶段资金设计和验证的分子测定的基础上。通过体外生物发光成像系统鉴定体液中的CAM剂的策略与Swaasth Inc开发的另一种药物发现技术补充，称为遗传表达和测量（GEMTM）。这些基于细胞的CAM剂检测技术将共同开发新技术，以监测依从性的客观度量，以研究CAM模态的研究。 Swaasth Inc.拥有 成功开发了分子试剂和高吞吐量基础设施 识别凸轮代理。预计宝石系统的可用性将有效利用 II期资金，以进一步扩大对各种CAM代理的检测并增强 临床环境中CAM模式的最小侵入性患者依从性测量。

项目成果

Curcumin and turmeric attenuate arsenic-induced angiogenesis in ovo.

• 发表时间: 2010-03
• 期刊: Alternative therapies in health and medicine
• 影响因子: 1.5
• 作者: P. Pantazis;A. Varman;C. Simpson‐Durand;J. Thorpe;S. Ramalingam;D. Subramaniam;C. Houchen;M. Ihnat;S. Anant;Rama P. Ramanujam

An Ethanol Extract of Hawaiian Turmeric: Extensive In Vitro Anticancer Activity Against Human Colon Cancer Cells.

夏威夷姜黄的乙醇提取物：对人类结肠癌细胞具有广泛的体外抗癌活性。

• 发表时间: 2015
• 期刊: Alternative therapies in health and medicine
• 影响因子: 1.5
• 作者: Dimas,Konstantinos;Tsimplouli,Chrisiida;Houchen,Courtney;Pantazis,Panayotis;Sakellaridis,Nikos;Tsangaris,GeorgeTh;Anastasiadou,Ema;Ramanujam,RamaP
• 通讯作者: Ramanujam,RamaP