PS08-002, DEV AND TESTING OF HIV PREV INTERVENTION TARGETING BLACK MSM/W

PS08-002，针对黑人 MSM/W 的 HIV 预防干预措施的开发和测试

• 批准号: 7924107
• 负责人: JENNIFER L LAUBY
• 金额: $ 33.33万
• 依托单位: PUBLIC HEALTH MANAGEMENT CORPORATION
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2012-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7924107
• 关键词: PS08; 002; DEV; TESTING; HIV

Description (provided by applicant): Black men who have sex with men (MSM) have the highest rates of HIV infection in the United States and represent a population in need of new HIV prevention interventions. Although 20 to 40% of Black MSM are estimated to have female partners, no interventions tailored to the needs of Black MSM/W have been developed and rigorously evaluated. Philadelphia Health Management Corporation proposes to develop, implement, and evaluate an individual-level intervention (ILI), titled "Connections", that will assist Black MSM/W to reduce their risk for acquiring and transmitting HIV infection. This intervention will address the effect of individual level factors, interpersonal relationships including sexual, peer and family relationships, and sociocultural influences on the sexual risk behaviors of MSM/W. The intervention will consist of six counseling sessions held between a social worker (intervention specialist) and participant, and will be guided by three theoretical perspectives: an ecological perspective of behavior, stress and coping theory, and social cognitive theory. The COLOURS Organization, the sole agency in Philadelphia dedicated to exclusively serving the Black LGBT community, will be a key collaborator in the development and implementation of the intervention. The evaluation design utilizes a randomized controlled trial to test the effectiveness of the proposed intervention. Respondent Driven Sampling (RDS) will be used to recruit 250 HIV-positive and HIV-negative Black bisexuallyactive men into this study. The specific aims of this research are to: 1. develop a new theoretically-based individual-level HIV prevention intervention culturally tailored to the needs of HIV-positive and HIV-negative Black MSM/W; 2. evaluate the intervention with a randomized control group design, using RDS to recruit 250 Black MSM/W who do not inject drugs and who report recent unprotected sex; 3. assess the efficacy of the intervention and test the intervention model through the collection of behavioral risk assessments and HIV and STD testing at three time points: baseline, immediately post-intervention and three-months post-intervention; 4. examine and describe individual factors, interpersonal relationships and network factors, and socio-cultura factors that may affect risk behaviors for HIV infection and transmission among Black MSM/W; and, 5. develop recommendations for recruiting Black bisexually-active men and providing them with targeted HIV prevention interventions. Evaluation data collection will be conducted using ACASI. Data analysis will include Repeated Measures ANOVA to make assessments of changes over time and intervention dose effects and structural equation modeling to assess causal associations between factors in the conceptual model. This proposed study has significance for increasing our understanding various types of factors that may affect sexual risk behaviors of Black MSM/W as well as potentially providing an important new tool for HIV prevention specifically targeting the needs and risk behaviors of Black MSM/W.

描述（由申请人提供）：与男性发生性关系的黑人（MSM）在美国的艾滋病毒感染率最高，代表需要新的艾滋病毒预防干预措施的人群。尽管估计有20％至40％的黑色MSM具有女性伴侣，但未针对黑色MSM/W的需求量身定制并严格评估了干预措施。费城健康管理公司建议开发，实施和评估名为“连接”的个人级别干预措施（ILI），该干预措施将有助于黑人MSM/W减少其获取和传播HIV感染的风险。这种干预将解决个人层面因素，人际关系的影响，包括性，同伴和家庭关系以及社会文化影响对MSM/W的性风险行为的影响。干预措施将包括社会工作者（干预专家）与参与者之间举行的六次咨询会议，并以三种理论观点为指导：行为，压力和应对理论以及社会认知理论的生态学观点。颜色组织是费城唯一专门为黑人LGBT社区服务的代理机构，将是开发和实施干预措施的关键合作者。评估设计利用随机对照试验来测试拟议干预的有效性。受访者驱动的采样（RDS）将用于招募250个HIV阳性和HIV阴性的黑色双歧性化男性。这项研究的具体目的是：1。开发一种基于理论上的新型个人艾滋病毒预防干预措施，该干预根据HIV阳性和HIV阴性黑色MSM/W的需求量身定制。 2。使用RDS使用随机对照组设计评估干预措施，招募250个不注射药物并报告最近未受保护的性别的黑人MSM/W； 3。通过在三个时间点收集行为风险评估以及艾滋病毒和性病测试来评估干预措施的疗效，并测试干预模型：基线，干预后立即进行干预和三个月的干预后； 4.检查并描述可能影响黑人MSM/W之间的风险行为的个人因素，人际关系和网络因素以及可能影响艾滋病毒感染和传播风险行为的社会兴奋性因素；以及5。为招募黑人双性活跃的男性提供建议，并为他们提供有针对性的HIV预防干预措施。评估数据收集将使用ACASI进行。数据分析将包括重复测量方差分析，以评估随时间和干预剂量效应和结构方程模型的变化，以评估概念模型中因素之间的因果关系。这项拟议的研究对于增加了我们的理解各种因素具有重要意义，这些因素可能影响黑色MSM/W的性风险行为，并可能为预防HIV提供了重要的新工具，专门针对黑色MSM/W的需求和风险行为。