Functional Circuits as an Endophenotype for ADHD in Children

功能回路作为儿童多动症的内表型

基本信息

批准号：
7976333
负责人：
Damien A Fair
金额：
$ 8.29万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-10 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7976333
关键词：
Accounting Age Algorithms Architecture Attention Attention deficit hyperactivity disorder Award Behavior assessment Behavioral Biological Assay Biological Markers Brain Cerebellum Characteristics Child Classification Clinical Clinical Research Clinical assessments Cognitive Communities Dementia Development Dimensions Dorsal Emotional Environment Exhibits Family Functional Magnetic Resonance Imaging Funding Future Genetic Goals Graph Hand Health Sciences Heterogeneity Hyperactive behavior Imaging Techniques Impulsivity Investigation Knowledge Laboratories Length Magnetic Resonance Imaging Maps Measures Mental disorders Mentors Metric Neuroanatomy Neurobiology Oregon Pathway interactions Patients Pattern Performance Phenotype Population Population Control Procedures Process Psychiatry Psychopathology Public Health Regulation Relative (related person)Research Research Personnel Rest Scientist Series Severities Short-Term Memory Siblings Subgroup Symptoms System Training Translating United States National Institutes of Health Universities Variant Washington Work Writing Youth base career career development endophenotype experience human subject improved inattention insight medical schools meetings neural circuit neuropsychological novel patient population proband public health relevance remediation theories trait trend

项目摘要

DESCRIPTION (provided by applicant): I am a 2nd year postdoctoral research scientist who arrived at OHSU after postgraduate training first at Yale University School of Medicine, and subsequently Washington University School of Medicine in St. Louis where I primarily focused on examining typical development of brain organization using fMRI and functional connectivity MRI. My goal is to establish my own independent laboratory in a University setting examining typical and atypical brain development in relation to mental disorders. In particular, I have well thought out ideas for a series of investigations regarding the potential for brain connectivity as a potential endophenotype in ADHD. To conduct such work, I need to gain expertise in issues related to research application of behavioral and clinical assessment, cognitive measures, neuropsychological measures, human subjects issues with clinical populations, and to gain expertise in writing and grantsmanship related to clinical problems. This agenda is the focus of my career development/training plan. The research environment provided by Oregon Health and Science University and the mentor of this award (Dr. Joel Nigg) is outstanding and a perfect fit for my career goals. Dr. Nigg, while not a neuroimager, is a well-known ADHD researcher with more than 10 years of continuous NIH R01 level funding. He has extensive mentoring experience and collaborates with other ADHD researchers around the world, providing ample opportunity for me to meet and interact with experts in many aspects of clinical research. The Pathway to Independence award, with its dual emphasis on training and independence, is an excellent fit for my future career goals. Lay summary of the proposed research plan: It is well established that ADHD is a major public health concern. The proposed study uses a relatively new imaging technique, resting-state functional connectivity MRI, to examine specific circuits and the familiality of these circuits thought to be atypical in ADHD. The result from this study will advance our knowledge regarding the neurobiological underpinnings of ADHD, and assist in the improved characterization of homogeneous subtypes of future investigation. PUBLIC HEALTH RELEVANCE: It is well established that ADHD is a major public health concern. The proposed study uses a relatively new imaging technique, resting-state functional connectivity MRI, to examine specific circuits and the familiality of these circuits thought to be atypical in ADHD. The result from this study will advance our knowledge regarding the neurobiological underpinnings of ADHD, and assist in the improved characterization of homogeneous subtypes of future investigation.

描述（由申请人提供）：我是一名二年级博士后研究科学家，首先在耶鲁大学医学院和圣路易斯华盛顿大学医学院接受研究生培训后来到 OHSU，在那里我主要致力于研究使用功能磁共振成像和功能连接磁共振成像的大脑组织。我的目标是在大学环境中建立自己的独立实验室，检查与精神障碍相关的典型和非典型大脑发育。特别是，我对一系列关于大脑连接作为多动症潜在内表型的潜力的研究提出了深思熟虑的想法。为了进行这项工作，我需要获得与行为和临床评估、认知测量、神经心理学测量、临床人群的人类受试者问题的研究应用相关的问题的专业知识，并获得与临床问题相关的写作和资助方面的专业知识。这个议程是我职业发展/培训计划的重点。俄勒冈健康与科学大学和该奖项的导师（Joel Nigg 博士）提供的研究环境非常出色，非常适合我的职业目标。 Nigg 博士虽然不是神经影像学家，但却是一位著名的 ADHD 研究者，拥有超过 10 年的连续 NIH R01 级别资助。他拥有丰富的指导经验，并与世界各地的其他多动症研究人员合作，为我提供了充足的机会与临床研究许多方面的专家会面和互动。独立之路奖双重强调培训和独立，非常适合我未来的职业目标。拟议研究计划的简单摘要：众所周知，多动症是一个主要的公共卫生问题。拟议的研究使用一种相对较新的成像技术，即静息态功能连接 MRI，来检查特定回路以及这些回路的家族性，这些回路被认为在 ADHD 中是非典型的。这项研究的结果将增进我们对 ADHD 神经生物学基础的了解，并有助于改善未来研究的同质亚型的表征。公共卫生相关性：众所周知，多动症是一个主要的公共卫生问题。拟议的研究使用一种相对较新的成像技术，即静息态功能连接 MRI，来检查特定回路以及这些回路的家族性，这些回路被认为在 ADHD 中是非典型的。这项研究的结果将增进我们对 ADHD 神经生物学基础的了解，并有助于改善未来研究的同质亚型的表征。