MRC Centre for Synaptic Plasticity

MRC 突触可塑性中心

• 批准号: G0601841-E01/1
• 负责人: Graham Collingridge
• 金额: $ 215.21万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0601841-E01%2F1
• 关键词: MRC; Centre; Synaptic; Plasticity

The work of the MRC Centre for Synaptic Plasticity is aimed at obtaining a fuller understanding of how synapses work. Information is stored in our brains by alterations in the efficiency of communication at synapses and the MRC Centre is interested in understanding the molecular processes involved in this plasticity. Thus synaptic plasticity is critical for the correct wiring of the brain during development and enables learning and memory to occur throughout life. Pathological alterations in these mechanisms are likely to contribute to neurological and psychiatric disease. We work to understand the processes that underlie these plasticity mechanisms and how they relate to learning and memory.The MRC Centre for Synaptic Plasticity is strongly committed to the public understanding of science. Indeed, its Director is a founder member of the European DANA Alliance for the Brain. MRC Centre scientists present public lectures, such as at the British Association, give talks in local schools and at open days, and communicate with the press on topical issues. The MRC Centre will continue to strongly support such activities. Members of the Centre also collaborate closely with Bristol Neuroscience (BN) in their public engagement activities, including providing and manning displays at events such as the biennial ?Science Alive? event (Bristol), Bioscience Kids (Glasgow) and Science in the Gardens (Sheffield). One researcher within the MRC Centre has been made a Fellow of the Researchers in Residence Scheme and is currently doing a placement with a local secondary school.

MRC突触可塑性中心的工作旨在获得对突触如何工作的充分了解。信息通过改变突触的通信效率而存储在我们的大脑中，而MRC中心有兴趣了解这种可塑性所涉及的分子过程。因此，突触可塑性对于开发过程中大脑的正确接线至关重要，并使学习和记忆能够在一生中发生。这些机制的病理改变可能会导致神经系统和精神病疾病。我们努力了解这些可塑性机制及其与学习和记忆之间的关系的过程。MRC突触可塑性中心强烈致力于公众对科学的理解。的确，它的导演是欧洲达娜大脑联盟的创始人。 MRC中心科学家在英国协会和开放日进行了公开演讲，例如在英国协会上进行会谈，并就局部问题进行沟通。 MRC中心将继续强烈支持此类活动。该中心的成员还在公共参与活动中与布里斯托尔神经科学（BN）紧密合作，包括在诸如双年展？科学之类的活动中提供和曼宁展示？事件（布里斯托尔），生物科学儿童（格拉斯哥）和花园中的科学（谢菲尔德）。 MRC中心内的一名研究人员已成为居住计划研究人员的研究员，目前正在当地中学工作。