SPORE in Genitourinary Cancer

泌尿生殖系统癌症中的孢子

• 批准号: 7679116
• 负责人: COLIN P.N. DINNEY
• 金额: $ 223.33万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-25 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7679116
• 关键词: SPORE; Genitourinary; Cancer

DESCRIPTION (provided by applicant): The overall goal of this University of Texas M. D. Anderson Cancer Center Genitourinary SPORE in Bladder Cancer is to facilitate innovative translational research in the prevention, detection, and treatment of this disease leading to the elimination of bladder cancer as a major health problem. We have invested in several major translational research themes: identification of a novel class of genes referred to as "forerunners" whose involvement precedes the loss of function of major tumor suppressor genes in the development of cancer, identification of persons with an increased inherited and/or acquired risk of developing bladder cancer or recurring following therapy by molecular epidemiology, developing targeted bladder cancer therapies for advanced disease, and the development of improved therapy for superficial disease. To achieve these goals, our SPORE has assembled clinicians and basic scientists including urologists, medical oncologists, pathologists, molecular epidemiologists, molecular and cell biologists, biostatisticians, and experts in development of new technologies and informatics. The SPORE includes 4 inter-related projects that deal with 1) early detection of bladder cancer, 2) risk assessment for bladder cancer 3) biology and therapeutic targeting of the epidermal growth factor receptor in bladder cancer, and 4) improving therapy for superficial bladder cancer through adenoviral mediated gene therapy. These projects are supported by 4 Cores: (A) Administrative; (B) Pathology & Tissue Resources; (C). Biostatistics and Bioinformatics; and (D) Clinical Trials and Data Management. All of the scientific projects are translational in nature; focus on human bladder cancer; involve clinical and basic investigators and biostatisticians; interact with the other projects; and utilize Core resources. Innovative Developmental and Career Development Projects have brought new investigators into and stimulated the SPORE that is represented in each of the major projects. This SPORE addresses clinical dilemmas facing patients with all forms of bladder cancer, and will provide a critical component of a larger effort to develop effective strategies for chemoprevention, detection, molecular profiling and therapeutics, bioimmunotherapy, chemotherapy, supportive care, and community awareness. Achievement of the aims and objectives of this proposal will result in a major decrease in the incidence, morbidity and mortality of bladder cancer.

描述（由申请人提供）： 这位得克萨斯大学M. D. Anderson癌症中心的总体目标是膀胱癌的泌尿生殖器孢子，促进了对这种疾病的预防，检测和治疗方面的创新转化研究，导致消除膀胱癌作为主要的健康问题。 We have invested in several major translational research themes: identification of a novel class of genes referred to as "forerunners" whose involvement precedes the loss of function of major tumor suppressor genes in the development of cancer, identification of persons with an increased inherited and/or acquired risk of developing bladder cancer or recurring following therapy by molecular epidemiology, developing targeted bladder cancer therapies for advanced disease, and the development of improved浅表疾病的治疗。为了实现这些目标，我们的孢子已经组装了临床医生和基础科学家，包括泌尿科医生，医学肿瘤学家，病理学家，分子流行病学家，分子和细胞生物学家，生物统计学家以及新技术和信息学发展方面的专家。孢子包括4个相关的项目，这些项目应对1）早期发现膀胱癌，2）膀胱癌的风险评估3）生物学和膀胱癌表皮生长因子受体的治疗性靶向，以及4）改善通过腺病毒介导的基因治疗的膀胱癌表皮治疗。这些项目得到4个核心的支持：（a）行政； （b）病理和组织资源； （c）。生物统计学和生物信息学； （d）临床试验和数据管理。所有科学项目本质上都是翻译的。专注于人膀胱癌；参与临床和基本研究人员和生物统计学家；与其他项目互动；并利用核心资源。创新的发展和职业发展项目使新的研究人员进入了每个主要项目中所代表的孢子。该孢子解决了各种形式的膀胱癌患者面临的临床困境，并将为制定有效的化学预防，检测，分子分析和治疗剂，生物免疫疗法，化学疗法，支持性护理和社区熟悉的有效策略提供更大努力的关键组成部分。该提案的目标和目标的实现将导致膀胱癌的发病率，发病率和死亡率大大降低。