CYSTEINE TARGETED REDOX REGULATION OF PROTEINS HOW WIDESPREAD IS REGULATION BY SULPHINIC ACID FORMATION?

半胱氨酸靶向蛋白质氧化还原调节 亚磺酸形成的调节有多广泛？

• 批准号: G0600785/1
• 负责人: Philip Eaton
• 金额: $ 42.95万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0600785%2F1
• 关键词: CYSTEINE; TARGETED; REDOX; REGULATION; PROTEINS

Ischaemic heart disease is the most common cause of mortality in the Western world and accounts for more than 150,000 deaths per year in the U.K. When blood flow to a region of the heart is reduced by narrowing or blocking of a coronary artery (ischaemia), the heart muscle becomes injured and, if the blockage is severe, the heart muscle will die (infarct). This is essentially what happens during a heart attack. It is essential therefore that the flow in the blocked coronary artery is rapidly restored (reperfusion) if the heart muscle is to survive. During ischaemia and reperfusion toxic forms of oxygen (free radicals) are produced that damage crucial components of the cell, including proteins. We have developed several new methods that allow us to identify heart proteins that are oxidised by free radicals during ischaemia and reperfusion. The identification of these proteins will help us understand the mechanisms of injury during ischaemia and reperfusion and identify possible therapeutic strategies to combat injury during a heart attack.

缺血性心脏病是西方世界最常见的死亡原因，在英国每年导致超过 150,000 人死亡。当流向心脏某个区域的血流因冠状动脉狭窄或阻塞（缺血）而减少时，心肌受伤，如果阻塞严重，心肌就会死亡（梗塞）。这基本上就是心脏病发作期间发生的情况。因此，如果心肌要存活，被阻塞的冠状动脉中的血流必须迅速恢复（再灌注）。在缺血和再灌注过程中，会产生有毒形式的氧（自由基），从而损害细胞的关键成分，包括蛋白质。我们开发了几种新方法，使我们能够识别在缺血和再灌注过程中被自由基氧化的心脏蛋白质。这些蛋白质的鉴定将帮助我们了解缺血和再灌注期间的损伤机制，并确定可能的治疗策略来对抗心脏病发作期间的损伤。