Primary Care Provider Education on Common Disease Genetics

初级保健提供者常见疾病遗传学教育

• 批准号: 7742730
• 负责人: Ethylin Wang Jabs
• 金额: $ 58.7万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7742730
• 关键词: Academy; Address; Adult; Age related macular degeneration; Aging; American; Attitude; Awareness; Belief; Case Study; Chronic; Clinic; Clinical; Communication; Communication Tools; Complex; Data; Development; Discipline; Disease; Education; Effectiveness; Endocrinology; Epidemiologist; Exercise; Family; Family Physicians; General Practitioners; Genetic; Genetic Markers; Genetic Risk; Genetic Variation; Genetic screening method; Genomics; Goals; Grant; Health Communication; Health Professional; Healthcare; Helping Behavior; Hereditary Disease; Institution; Internal Medicine; Internist; Intervention; Interview; Lead; Life; Macular degeneration; Malignant neoplasm of prostate; Measures; Medical; Medical Genetics; Medicine; Multimedia; Non-Insulin-Dependent Diabetes Mellitus; Onset of illness; Ophthalmology; Outcome; Patients; Physicians; Population; Predisposition; Primary Care Physician; Primary Health Care; Process; Professional Education; Professional counselor; Provider; Psychologist; Questionnaires; Randomized Controlled Trials; Research Personnel; Risk; Science; Surveys; Testing; Training; Universities; age related; cancer type; clinical practice; clinically significant; communication aid; design; genome wide association study; improved; innovation; medical schools; meetings; member; oncology; programs; response; skills; therapy design

DESCRIPTION (provided by applicant): Primary care providers (PCPs), especially physicians, are becoming increasingly responsible for advising patients regarding common disease genetic testing. Genome-wide association studies (GWASs) have identified common gene variants which are associated with a range of common adult-onset diseases, such as age-related macular degeneration, prostate cancer and type II diabetes. The clinical significance of these GWAS results remains unclear and controversial. However, commercial companies are already offering direct-to-consumer genetic tests for common diseases using these findings. In order to be prepared for patient inquiries about these tests and perhaps the eventual integration of genomics into their clinical practice, PCPs need to be able to understand, evaluate and communicate with their patients about GWAS findings, genetic risk and genetic tests. At present, the evidence suggests that PCPs are not prepared for these genomic developments. The overall objectives of this study are to: (1) effectively educate PCPs to evaluate genetic information and incorporate it only when appropriate into their clinical practice; and (2) improve provider-patient communication about genomics and genetic testing. To achieve these goals, the specific aims are to: 1) conduct a survey of physicians through the American Association of Family Practitioners (AAFP) and the American Board of Internal Medicine (ABIM), interviews with PCPs, and meetings among expert consultants to inform the design, content and development of an intervention designed to educate PCPs about common disease genetics and genetic testing; 2) develop and pilot the intervention components such as case study vignettes, communication videos, and handheld risk communication aids; and 3) plan a randomized controlled trial (RCT) using the educational and communication intervention to evaluate its effectiveness in improving PCPs' understanding and communication of common disease genetics. This planning grant will involve diverse healthcare settings at Mount Sinai School of Medicine, Mayo Clinic, and Duke University to understand PCPs' current beliefs, attitudes and understanding of genomics and genetic testing, and whether an innovative multimedia intervention can change their behavior and help them effectively communicate information about genetics of common diseases.

描述（由申请人提供）： 初级保健提供者 (PCP)，尤其是医生，越来越多地负责为患者提供关于常见疾病基因检测的建议。全基因组关联研究 (GWAS) 已经确定了与一系列常见成人发病疾病相关的常见基因变异，例如年龄相关性黄斑变性、前列腺癌和 II 型糖尿病。这些 GWAS 结果的临床意义仍不清楚且存在争议。然而，商业公司已经利用这些发现直接向消费​​者提供常见疾病的基因测试。为了准备好接受患者对这些测试的询问，并可能最终将基因组学整合到他们的临床实践中，PCP 需要能够理解、评估并与患者沟通 GWAS 结果、遗传风险和基因测试。目前，有证据表明，PCP 尚未为这些基因组发展做好准备。本研究的总体目标是：(1) 有效地教育 PCP 评估遗传信息，并仅在适当时将其纳入临床实践； (2) 改善提供者与患者有关基因组学和基因检测的沟通。为了实现这些目标，具体目标是：1）通过美国家庭医生协会（AAFP）和美国内科医学委员会（ABIM）对医生进行调查，采访PCP，并召开专家顾问会议，以提供信息旨在对 PCP 进行常见疾病遗传学和基因检测教育的干预措施的设计、内容和开发； 2）开发和试点干预措施，例如案例研究 插图、沟通视频和手持式风险沟通辅助工具； 3) 计划一项随机对照试验 (RCT)，利用教育和交流干预措施来评估其在提高 PCP 对常见疾病遗传学的理解和交流方面的有效性。这笔规划拨款将涉及西奈山医学院、梅奥诊所和杜克大学的不同医疗保健机构，以了解 PCP 目前对基因组学和基因检测的信念、态度和理解，以及创新的多媒体干预措施是否可以改变他们的行为并帮助他们有效传达常见疾病遗传学信息。