Phamacology Core

药理学核心

• 批准号: 7918977
• 负责人: Noelle Sevilir Williams
• 金额: $ 18.75万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7918977
• 关键词: Address; Animal Model; Behavior; Biological; Biological Assay; Cancer Center; Cancer Patient; Cell Culture Techniques; Cell Line; Cessation of life; Characteristics; Chemicals; Chemistry; Clinical; Commit; Communities; Comprehensive Cancer Center; Core Facility; Development; Disease; Dose; Drug Kinetics; Ensure; Equipment; Evaluation; Experimental Designs; Future; Goals; In Vitro; Individual; Ireland; Malignant Neoplasms; Measurement; Medical center; Metabolic; Metabolism; Modeling; Molecular; Monitor; Mycoplasma; NCI-Designated Cancer Center; Operative Surgical Procedures; Patients; Pharmacology; Plasma Proteins; Positioning Attribute; Process; Program Research Project Grants; Property; Protein Binding; Research; Research Personnel; Resource Sharing; Resources; Rodent Model; Screening procedure; Services; Solubility; Standardization; Structure; Testing; Time; Toxic effect; Universities; University Hospitals; Work; Xenograft procedure; absorption; animal colony; animal resource; anticancer research; base; chemical synthesis; design; experience; fighting; in vivo; member; mouse development; novel; novel therapeutics; pathogen; programs; research study; small molecule; success; tumor

The Pharmacology Core facility will be responsible for the design, execution, and analysis of experiments that address metabolic stability, general in i//Vo toxicity, pharmacokinetics, and in vivo efficacy of anti-cancer compounds generated by this Program Project Grant (PPG). In addition, they will maintain the cell lines, animal resources, and equipment that support these functions. It is anticipated that all four projects of this PPG may potentially have need for the services provided by this Core facility. In addition, the Core will serve as a resourcefor members of the UT Southwestern Medical Center (UTSWMC) Comprehensive Cancer Center needing assistance with pharmacological assays. Since there are no other facilities here that can provide in-depth analysis of the behavior of novel small molecules in an in vivo setting, the creation of such a shared resource has the potential to impact the future development of translational cancer research at UTSWMC. The services provided by the Core facility will include: in vitro screening of compounds against a broad tumor panel; characterization of the metabolic stability of individual compounds in vitro and identification of metabolites as necessary; assessment of the solubility, plasma protein binding, and absorption characteristics of compounds in vitro; determination of the maximum in vivo tolerated dose and a preliminary assessment of toxicity; assessment of the distribution of compounds in small rodent models (pharmacokinetics); and development of mouse xenograft or other appropriate models for assessment of compound efficacy in vivo. The Pharmacology Core facility will work closely with PPG chemists to refine the structure of individual compounds so that characteristics that favor optimal efficacy in vivo will be maximized. There is an urgent need for new therapeutics to fight cancer, which in 2005 was responsible for over 500,000 deaths. The overall goal of this Program Project grant (PPG) is to discover and characterize synthetic, small molecule compounds that may be effective in the treatment of this disease. The Pharmacology Core facility will perform in vitro and in vivo measurements of compound concentration, toxicity, and efficacy in animal models. The overall goal of the Core is to guide chemical synthesis efforts of PPG projects in such a way that novel molecules with the best chance of clinical success in cancer patients are generated.

药理学核心设施将负责实验的设计，执行和分析 该解决了代谢稳定性，I //中的一般性毒性，药代动力学和抗癌的体内功效 该程序项目赠款（PPG）生成的化合物。另外，它们将维护细胞系， 动物资源和支持这些功能的设备。预计所有四个项目 PPG可能有可能需要该核心设施提供的服务。此外，核心将服务 作为UT西南医学中心（UTSWMC）综合癌症的资源 需要在药理测定方面提供帮助的中心。由于这里没有其他设施可以 在体内环境中对新型小分子的行为进行深入分析，创建这种 共享资源有可能影响转化癌研究的未来发展 UTSWMC。核心设施提供的服务将包括：在体外筛选化合物针对A 宽肿瘤面板；体外化合物的代谢稳定性的表征 必要时鉴定代谢产物；评估溶解度，血浆蛋白结合和 体外化合物的吸收特征；确定最大体内耐受剂量和A 毒性初步评估；评估小啮齿动物模型中化合物的分布 （药代动力学）；和开发小鼠异种移植或其他适当模型，以评估 体内复合功效。药理学核心设施将与PPG化学家紧密合作，以完善 各个化合物的结构，以使在体内有利于最佳功效的特征将被最大化。 迫切需要新的治疗剂与癌症作斗争，2005年造成超过500,000 死亡人数。该计划项目赠款（PPG）的总体目标是发现和表征合成的小型 可能有效治疗该疾病的分子化合物。药理学核心设施 将在体外和体内测量复合浓度，毒性和动物功效 型号。核心的总体目标是以这种方式指导PPG项目的化学合成工作 在癌症患者中产生最佳临床成功的新分子。