Molecular organisation of the secretory and endocytic pathways

分泌和内吞途径的分子组织

• 批准号: G0501725/1
• 负责人: Martin Lowe
• 金额: $ 19.34万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0501725%2F1
• 关键词: Molecular; organisation; secretory; endocytic; pathways

All animal cells release proteins into and take up proteins from the surrounding fluid. They also transport proteins between internal compartments, each of which has a unique composition and a specific function. Transport out of and into cells, and between internal compartments, is crucial for the normal functioning of cells, as well as the inter-cellular communication that is essential in all animals. Defects in these transport steps are associated with many diseases. It is therefore important we understand how this transport operates at the molecular level. The aim of the work in this application is to apply the technique of high-resolution electron microscopy, combined with a variety of modern molecular approaches, to increase our understanding of a number of key transport steps. This will allow us to gain insights into how the transport pathways function in a healthy cell, and consequently how defects in particular aspects of this transport may contribute to disease.

所有动物细胞都会从周围液体中释放蛋白质并吸收蛋白质。它们还在内部隔室之间运输蛋白质，每个隔室具有独特的组成和特定的功能。从细胞中和内部隔室之间的运输对于细胞的正常功能以及在所有动物中必不可少的细胞间通信至关重要。这些运输步骤中的缺陷与许多疾病有关。因此，重要的是我们了解该运输如何在分子水平上运行。该作品在本应用程序中的目的是应用高分辨率电子显微镜的技术，再加上各种现代分子方法，以提高我们对许多关键运输步骤的理解。这将使我们能够深入了解运输途径在健康细胞中的运作方式，因此，该运输的特定方面的缺陷如何有助于疾病。