Predoctoral Training Program in Molecular Pharmacology

分子药理学博士前培训项目

• 批准号: 7266927
• 负责人: MATTHEW M AMES
• 金额: $ 17.65万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-10 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7266927
• 关键词: Molecular; Pharmacology; Training Programs; pre-doctoral

DESCRIPTION (provided by applicant): The primary goal of the Ph.D. Training Program in Molecular Pharmacology and Experimental Therapeutics (MPET) in the Mayo Graduate School is the development of independent investigators capable of directing outstanding research Programs in academia, industry or other settings. The faculty is comprised of 18 well funded, independent investigators, who focus on a continuum of research encompassing studies from basic molecular and genetic aspects of disease through drug discovery and development of novel therapies for cardiovascular, neurodegenerative and malignant diseases. This faculty provides training opportunities in areas that include computational chemistry, molecular mechanisms of drug action and resistance, novel therapeutic strategies, preclinical and clinical pharmacology, and pharmacogenomics of genes associated with drug responses. Twenty-one predoctoral students are currently enrolled in the MPET track of the Biomedical Sciences Ph.D. Program. A rigorous didactic curriculum includes a series of Core Curriculum courses that ensures a strong fundamental knowledge in biochemistry, molecular biology, genetics, statistics, cell biology and pharmacology and a series of tutorial-based courses to provide students with advanced training in molecular pharmacology. During their first two years of study, students complete 3 laboratory rotations and select a laboratory for their thesis research. They sit for comprehensive written and oral qualifying examinations at the end of year two. After developing a thesis written proposal delineating the questions and approaches to be pursued in the thesis research, the thesis committee reviews the proposed research at the first committee meeting. Students present work-in-progress updates on their research projects to MPET faculty and students each year. Students are strongly encouraged to publish completed work in a timely manner and to attend national meetings to present their work. The average time to completion of the Ph.D. Program is approximately 4.8 years. During the fourth and fifth years of training, students are mentored to identify outstanding postdoctoral training opportunities as the next step in their career development. Graduates of the MPET Ph.D. training program have outstanding track records, with many now serving as principal investigators directing their own laboratories.

描述（由申请人提供）：博士学位的主要目标。梅奥研究生院的分子药理学和实验治疗学 (MPET) 培训项目旨在培养能够在学术界、工业界或其他环境中指导杰出研究项目的独立研究人员。该学院由 18 名资金充足的独立研究人员组成，他们专注于一系列研究，包括从疾病的基本分子和遗传方面到药物发现和心血管、神经退行性和恶性疾病新疗法的开发。该学院提供的培训机会包括计算化学、药物作用和耐药性的分子机制、新颖的治疗策略、临床前和临床药理学以及与药物反应相关的基因的药物基因组学。目前有 21 名博士前学生正在就读生物医学科学博士的 MPET 课程。程序。严格的教学课程包括一系列核心课程，确保学生在生物化学、分子生物学、遗传学、统计学、细胞生物学和药理学方面掌握扎实的基础知识，以及一系列辅导课程，为学生提供分子药理学的高级培训。在学习的前两年中，学生完成 3 次实验室轮转并选择一个实验室进行论文研究。他们在第二年末参加综合笔试和口试资格考试。在制定论文书面提案，描述论文研究中要追求的问题和方法后，论文委员会在第一次委员会会议上审查拟议的研究。学生每年都会向 MPET 教职员工和学生展示其研究项目的进展情况。强烈鼓励学生及时发表已完成的作品并参加全国会议展示他们的作品。完成博士学位的平均时间项目时间约为4.8年。在第四年和第五年的培训中，学生将被指导寻找优秀的博士后培训机会，作为他们职业发展的下一步。 MPET 博士毕业生培训计划有着出色的记录，许多人现在担任主要研究人员，指导自己的实验室。