Axonal transport, protein trafficking and neurological disease

轴突运输、蛋白质运输和神经系统疾病

• 批准号: G0501573/1
• 负责人: Christopher Miller
• 金额: $ 156.85万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0501573%2F1
• 关键词: Axonal; transport; protein; trafficking; neurological

There are currently no effective treatments for motor neuron disease/amyotrophic lateral sclerosis. Indeed, the mechanisms by which motor neurons die in ALS are not even properly understood. However, one of the earliest defects seen in models of the disease is disruption to movement of proteins through the cell by a process termed ?axonal transport?. Defective axonal transport is also seen in several other neurodegenerative diseases. This programme of studies is therefore to gain insight into the mechanisms by which axonal transport is damaged in ALS. We will disseminate our findings to the public in a variety of ways. Firstly, both Chris Miller and Chris Shaw regularly speak to lay audiences of patients and carers on their research at Motor Neurone Disease Association meetings. Chris Shaw has also communicated research findings and strategies on ALS to the public via radio and television broadcasts. In addition, the IOP hosts Open Days (which have been funded by the MRC) in which members of the public, through a series of talks and hands-on research presentations, are exposed to the wide range of neurodegenerative diseases-related research projects that are currently underway in the IOP. Finally, our findings are listed on the IOP WEB pages and receive exposure through the IOP press office.

目前尚无有效的运动神经元疾病/肌萎缩性侧面硬化症的治疗方法。确实，运动神经元在ALS中死亡的机制甚至没有正确理解。但是，在疾病模型中看到的最早的缺陷之一是通过称为轴突运输的过程对蛋白质运动的破坏。在其他几种神经退行性疾病中也可以看到轴突运输缺陷。因此，该研究计划是为了深入了解ALS中轴突运输受损的机制。我们将以各种方式向公众传播我们的发现。首先，克里斯·米勒（Chris Miller）和克里斯·肖（Chris Shaw）经常在运动神经元疾病协会会议上对患者和护理人员的研究观众讲话。克里斯·肖（Chris Shaw）还通过广播和电视广播向公众传达了ALS的研究结果和策略。此外，IOP主持人的开放日（由MRC资助），在该活动中，通过一系列的会谈和动手研究演讲，公众接触了IOP目前正在进行的与神经退行性疾病相关的广泛研究项目。最后，我们的发现在IOP网页上列出，并通过IOP新闻办公室接收曝光。