The Denver Network of the NHLBI Progenitor Cell Biology Consortium

NHLBI 祖细胞生物学联盟丹佛网络

• 批准号: 7678306
• 负责人: Dennis Roop
• 金额: $ 3.87万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7678306
• 关键词: Area; Arts; Award; Blood Vessels; Cell Differentiation process; Cell Lineage; Cells; Cellular biology; Clinical; Collaborations; Colorado; Core Facility; Development; Disease; Faculty; Funding; Goals; Health; Hematological Disease; Hematopoietic; Hematopoietic stem cells; Institutes; Lung; Lung diseases; Mentors; Methods; National Heart, Lung, and Blood Institute; Reagent; Recruitment Activity; Regenerative Medicine; Research; Research Training; Science; Skin; Stem cells; Therapeutic; Time; Training Programs; Translational Research; Translations; Universities; Viral; discount; follower of religion Jewish; improved; induced pluripotent stem cell; member; new technology; novel; programs; stem; stem cell biology

DESCRIPTION (provided by applicant): This application proposes to establish the Denver Network of the NHLBI Progenitor Cell Biology Consortium. The timing of this RFA coincides perfectly with new a multi-institutional stem cell initiative in Denver. A new Regenerative Medicine and Stem Cell Biology Program (RMSCBP) was established at the University of Colorado Denver (UCD) in 2007, which has resulted in the recruitment of 7 new faculty whose research efforts focus on stem cell biology. In concert with this initiative, National Jewish Health (NJH) recruited two outstanding lung stem cell biologists. These new recruits have joined 24 existing faculty to form a multi-institutional, comprehensive stem cell program consisting of over 30 primary members who have access to state-of-the-art Core Facilities at discounted rates (http://www.uchsc.edu/stemcell/). The projects proposed in this application are excellent examples of existing collaborations that were initiated within the last year as a result of these new stem cell initiatives. Specifically, this application proposes to utilize the existing expertise within the Denver Network in the areas of hematopoietic and skin stem cell biology to generate improved reagents to identify and characterize lung and vascular progenitor cell lineages. In addition, to facilitate the development of new methods for isolating lung and vascular stem and progenitor cells, and for directing the differentiation of these cells to desired cell fates, we propose to establish new Core Facilities which utilize novel technologies developed by members of the Denver Network. Finally, the therapeutic potential of conditionally immortalized long-term hematopoietic stem cells and induced pluripotent stem (iPS) cells, which will be generated by novel non-viral methods, will be explored for the treatment of hematological and lung disorders. The translational and clinical aspects of this application, as well as the proposed mentoring and training program, will be greatly facilitated by the Colorado Clinical Translational Science Institute (CCTSI). The clinical and translation sciences, research, and training at UCD and its six Affiliates, which includes NJH, were recently successfully integrated into the CCTSI following the receipt of a CTSA award of $76 million.

描述（由申请人提供）：本申请提议建立NHLBI祖细胞生物联盟的丹佛网络。该RFA的时机与丹佛的新型多机构干细胞倡议完美吻合。 2007年，在科罗拉多大学丹佛大学（UCD）建立了一项新的再生医学和干细胞生物学计划（RMSCBP），这导致了7位新教师的招募，其研究工作着重于干细胞生物学。与这项倡议一致，国家犹太人健康（NJH）招募了两名杰出的肺部干细胞生物学家。这些新的新兵已加入了24名教职员工，形成了一个多机构的，全面的干细胞计划，包括30多位主要成员，他们有折扣价（http://wwwww.uchsc.edu/stemcell/），他们有30多名主要成员。本应用程序中提出的项目是由于这些新的干细胞计划在去年启动的现有合作的绝佳例子。具体而言，该应用建议在造血和皮肤干细胞生物学领域利用丹佛网络中的现有专业知识来生成改进的试剂，以识别和表征肺和血管祖细胞谱系。此外，为了促进开发隔离肺和血管茎和祖细胞的新方法，以及将这些细胞的分化转化为所需的细胞命运，我们建议建立新的核心设施，利用丹佛网络成员开发的新技术。最后，将探索有条件永生的长期造血干细胞和诱导多能干（IPS）细胞的治疗潜力，该细胞将通过新型的非病毒方法产生，用于治疗血液学和肺部疾病。科罗拉多州临床转化科学研究所（CCTSI）将极大地促进本应用程序的转化和临床方面以及拟议的指导和培训计划。在收到了7600万美元的CTSA奖励后，最近在UCD及其六个分支机构（包括NJH）的临床和翻译科学，研究和培训成功地集成了CCTSI。