UK MAD BEAMLINE AT ESRF

ESRF 的英国 MAD 光束线

• 批准号: G0500367/1
• 负责人: David Stuart
• 金额: $ 216.56万
• 依托单位: Medical Research Council
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0500367%2F1
• 关键词: UK; MAD; BEAMLINE; ESRF

Macromolecular crystallography is the most powerful method available to biologists to determine the precise three-dimensional arrangement of atoms within proteins and other complex biological molecules. By tuning the wavelength of X-rays such that they interact strongly with certain atoms within the molecule researchers can more easily unravel the complete structure. This method is called MAD and this grant asks for funds to provide open access to all UK researchers to one of the top MAD beamlines in Europe. The output of BM14 will be several hundred new structures some of which are likely to be of great biomedical importance.

大分子晶体学是生物学家可用的最强大方法，可确定蛋白质和其他复杂生物分子内原子的精确三维排列。通过调整X射线的波长，以使它们与分子研究人员中某些原子的相互作用牢固相互作用，可以更轻松地揭开完整的结构。这种方法称为疯狂，该赠款要求资金向所有英国研究人员提供公开访问欧洲最高的疯狂束线之一。 BM14的输出将是几百个新结构，其中一些可能具有极大的生物医学重要性。