CLINICAL TRIAL: HORMONE GEL APPLIED TO WOMEN WITH PITUITARY GLAND PROBLEMS

临床试验：激素凝胶适用于患有脑垂体问题的女性

• 批准号: 8173588
• 负责人: THEODORE FRIEDMAN
• 金额: $ 4.18万
• 依托单位: CHARLES R. DREW UNIVERSITY OF MED & SCI
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173588
• 关键词: Blood; Blood Tests; Body Composition; Clinical Trials; Cognition; Computer Retrieval of Information on Scientific Projects Database; Estrogens; Fatigue; Functional disorder; Funding; Future; Gel; Gonadal Steroid Hormones; Grant; Hormones; Hydrocortisone; Institution; Libido; Measures; Medical center; Muscle function; Pituitary Gland; Play; Preparation; Production; Quality of life; Questionnaires; Research; Research Personnel; Resources; Role; Series; Serum; Sex Functioning; Source; Testing; Testosterone; Thyroid Gland; United States National Institutes of Health; Universities; Woman; absorption; dosage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Women who have pituitary gland dysfunction often have decreased production of a number of hormones, including thyroid hormonee, cortisol and sex hormones like estrogen and testosterone. As part of the treatment, these deficient hormones are normally replaced with exception of testosterone in women. However, testosterone may play an important role in women especially in terms of maintaining lean body mass and enhancing libido and general well being. This study, in general, looks to identify the effects of low testosterone in women with pituitary dysfunction as compared with normal women. At Charles R. Drew University, the subjects will undergo baseline blood tests for homone levels, tests for body composition and muscle function, as well as questionnaire tests evaluating fatigue, cognition, subjective sexual function and quality of life. At UCLA Medical Center, objective measures of sexual function will be assessed. Also at Charles R. Drew University, the absorption of a testosterone gel preparation given for seven days will be measured through a series of blood draws to determine testosterone serum concentrations. This will enable determination of appropriate replacement dosage of testosterone gel for a future study.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 患有垂体功能障碍的女性通常会降低许多激素的产生，包括甲状腺激素，皮质醇和性激素，如雌激素和睾丸激素。作为治疗的一部分，这些不足的激素通常被女性睾丸激素除外。但是，睾丸激素可能在女性中发挥重要作用，尤其是在维持瘦体重和增强性欲和一般健康方面。总的来说，这项研究旨在确定低睾丸激素对垂体功能障碍的女性的影响，与正常女性相比。在查尔斯·R·德鲁大学（Charles R. Drew University），受试者将接受基线血液测试，以实现个人水平，身体成分和肌肉功能的测试，以及评估疲劳，认知，主观性功能和生活质量的问卷测试。在加州大学洛杉矶分校医疗中心，将评估性功能的客观度量。同样在查尔斯·R·德鲁大学（Charles R. Drew University），将通过一系列抽血来测量睾丸激素凝胶制剂的吸收，以确定睾丸激素血清浓度。这将使确定适当的替代睾丸激素凝胶的适当替代剂量进行未来的研究。