GENIS

杰尼斯

• 批准号: 8173626
• 负责人: YUAN XIANG-MENG
• 金额: $ 21.5万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173626
• 关键词: African American; Beta Cell; Cell physiology; Computer Retrieval of Information on Scientific Projects Database; DNA; Development; Diabetes Mellitus; Disease susceptibility; Funding; Genes; Genetic Markers; Glucose; Goals; Grant; Health; Individual; Institution; Insulin; Metabolism; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Overweight; Phenotype; Population; Predisposition; Preventive Intervention; Research; Research Personnel; Resources; Risk; Sampling; Source; Susceptibility Gene; United States National Institutes of Health; Variant; abstracting; base; diabetic patient; epidemiology study; genetic epidemiology; high risk; human TCF7L2 protein; insulin secretion; non-diabetic; zinc-binding protein

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Abstract of project: Recent large-scale genetic epidemiology studies have identified newly defined susceptibility genes for Type 2 Diabetes. However, the pathobiological mechanisms by which these putative disease susceptibility loci predispose to diabetes remains to be further defined. The goal of the study is to determine whether genetic markers such as DNA variants in the zinc transporter SLC30A8 or the transcription factor 7-like 2 (TCF7L2) genes can be used to identify individuals with increased susceptibility to impaired beta-cell function and the eventual development of diabetes within an at risk African American population (AA). The specific aims are: 1) Establish a well-phenotyped sample of overweight/obese, non-diabetic African-American subjects that undergo careful characterization of glucose/insulin metabolism in the GCRC setting and 2) Determine if variants in SLC308A8 and TCF7L2 genes are associated with impaired insulin secretion in overweight/obese African Americans. These studies should eventually lay the groundwork for 'Predictive Health' models based on genetic markers that will enable clinicians to more effectively identify high-risk pre-diabetic patients and target preventive interventions.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 项目摘要： 最近的大规模遗传流行病学研究已经确定了2型糖尿病的新定义的易感基因。但是，这些假定的疾病易感性基因座易感糖尿病的病理生物学机制尚待进一步定义。该研究的目的是确定诸如锌转运蛋白SLC30A8中的DNA变异或转录因子7样2（TCF7L2）基因等遗传标志物是否可用于识别具有增加易感性β细胞功能易感性的个体，并且在非洲美国人（AA）中最终的糖尿病发展（AA）。 The specific aims are: 1) Establish a well-phenotyped sample of overweight/obese, non-diabetic African-American subjects that undergo careful characterization of glucose/insulin metabolism in the GCRC setting and 2) Determine if variants in SLC308A8 and TCF7L2 genes are associated with impaired insulin secretion in overweight/obese African Americans.这些研究最终应基于遗传标记的“预测健康”模型为基础，这将使临床医生能够更有效地识别糖尿病前患者并靶向预防性干预措施。