CLINICAL TRIAL: TESTOSTERONE DOSE RESPONSE IN SURGICALLY POSTMENOPAUSAL WOMEN

临床试验：绝经后女性手术后的睾酮剂量反应

• 批准号: 8173594
• 负责人: Matthew H. Ho
• 金额: $ 4.18万
• 依托单位: CHARLES R. DREW UNIVERSITY OF MED & SCI
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173594
• 关键词: Adverse effects; Androgens; Apolipoproteins; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Dose; Fatty acid glycerol esters; Funding; Grant; Institution; Leg; Lipids; Lipoproteins; Menopause; Neurocognitive; Outcome; Plasma; Postmenopause; Research; Research Personnel; Resources; Sex Functioning; Source; Testosterone; Thigh structure; United States National Institutes of Health; Woman; insulin sensitivity; muscle strength; particle; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 1. Primary objective of this study is to establish testosterone dose-response relationships in surgically menopausal women with low testosterone concentrations for a range of androgen-dependent outcomes, including sexual function, fat-free mass, thigh muscle strength and leg power, several domains of neurocognitive function, plasma lipids, apolipoproteins and lipoprotein particles, and insulin sensitivity. 2. The secondary objective is to determine the range of testosterone doses and subsequent plasma testosterone concentrations that are associated with improvements in sexual, physical and neurocognitive functions and that can be safely administered to women without significant adverse effects.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 1. Primary objective of this study is to establish testosterone dose-response relationships in surgically menopausal women with low testosterone concentrations for a range of androgen-dependent outcomes, including sexual function, fat-free mass, thigh muscle strength and leg power, several domains of neurocognitive function, plasma lipids, apolipoproteins and lipoprotein particles, and insulin sensitivity. 2。次要目标是确定与性，身体和神经认知功能的改善相关的睾丸激素剂量和随后的血浆睾丸激素浓度，并且可以安全地施用给女性而没有显着不良影响。