Habits and cues in alcohol drinking: Dynamic striatal activity

饮酒的习惯和线索：动态纹状体活动

• 批准号: 7810531
• 负责人: Donita L Robinson
• 金额: $ 22.2万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7810531
• 关键词: Address; Alcohol consumption; Alcohols; Animal Model; Anticonvulsants; Arts; Behavior; Behavioral; Benchmarking; Brain; Clinic; Consumption; Corpus striatum structure; Cues; Data; Development; Dopamine; Dorsal; Dose; Effectiveness; Employment; Event; Extinction (Psychology); Funding; Future; Glutamates; Goals; Grant; Habits; Lead; Link; Methodology; Modeling; Naltrexone; National Institute on Alcohol Abuse and Alcoholism; Neurons; Opioid Receptor; Parents; Pharmaceutical Preparations; Pharmacotherapy; Play; Rattus; Recovery; Reinforcement Schedule; Relapse; Research Personnel; Resistance; Rewards; Role; Scanning; Schedule; Self Administration; Self-Administered; Strategic Planning; Sucrose; Testing; Therapeutic; Therapeutic Effect; Time; Training; Treatment Efficacy; United States National Institutes of Health; Yin; alcohol effect; alcohol reinforcement; alcohol response; alcohol reward; alcohol seeking behavior; alcoholism therapy; behavioral pharmacology; comparative; comparative effectiveness; drinking; effectiveness research; extracellular; gamma-Aminobutyric Acid; improved; innovation; novel; parent grant; pre-clinical; preclinical study; prevent; public health relevance; research study; response; topiramate; transmission process

DESCRIPTION (provided by applicant): This is a Competitive Revision Application in response to NOT-OD-09-058 "NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications." The parent R01 grant investigates neurodynamics (neuronal firing, dopamine release) in the dorsal striatum during goal-directed and habitual alcohol drinking and relapse-like behavior. The supplement will compare the behavioral pharmacology of therapeutic drugs on goal-directed versus habitual alcohol drinking and relapse-like behavior. The resulting data may have a profound impact on the interpretation of preclinical studies of therapeutic drugs for treatment of alcoholism, and could lead to improved preclinical animal models of alcohol drinking and relapse-like behavior. These non-overlapping aims are synergistic with the parent grant and will lead to future studies to determine the effect of therapeutic drugs on neurodynamics in the striatum during alcohol self-administration and relapse-like behavior. The supplemental aims comply with the justification of the Recovery Act by enabling hiring of new full-time and part-time staff. The supplemental aims also address the goal of the NIAAA Strategic Plan to improve animal models in medication development and the NIH goal of comparative effectiveness research (preclinical). PUBLIC HEALTH RELEVANCE: This competitive revision will expand the parent grant by comparatively evaluating the therapeutic efficacy of naltrexone and topiramate on goal-directed versus habit-driven alcohol drinking and relapse-like behavior. In compliance with the purpose of the Recovery Act, it will create new full-time and part-time employment.

描述（由申请人提供）：这是一份竞争性修订申请，旨在回应 NOT-OD-09-058“NIH 宣布恢复法案资金可用于竞争性修订申请”。母公司 R01 资助研究了目标导向和习惯性饮酒以及复发样行为期间背侧纹状体的神经动力学（神经元放电、多巴胺释放）。该补充剂将比较治疗药物对目标导向行为与习惯性饮酒和复发样行为的行为药理学。由此产生的数据可能对治疗酒精中毒的治疗药物的临床前研究的解释产生深远的影响，并可能导致改善饮酒和复发样行为的临床前动物模型。这些不重叠的目标与家长资助具有协同作用，并将导致未来的研究，以确定治疗药物在自我饮酒和复发样行为期间对纹状体神经动力学的影响。补充目标通过允许雇用新的全职和兼职员工来符合《复苏法案》的合理性。补充目标还涉及 NIAAA 战略计划中改善药物开发动物模型的目标以及 NIH 比较有效性研究（临床前）的目标。 公共健康相关性：本次竞争性修订将通过比较评估纳曲酮和托吡酯对目标导向型与习惯驱动型饮酒和复发样行为的治疗效果，扩大家长资助范围。根据《复苏法案》的目的，它将创造新的全职和兼职就业机会。