Core--Echocardiography and Hemodynamic Function

核心--超声心动图和血流动力学功能

• 批准号: 7898657
• 负责人: Margaret M Redfield
• 金额: $ 34.57万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7898657
• 关键词: Animal Model; Biology; Canis familiaris; Cardiovascular system; Echocardiography; Experimental Models; Heart failure; Human; Hypertension; Kidney; Modeling; Mus; Peptides; Production; Structure; Systolic heart failure; Therapeutic; Transgenic Mice; Ventricular; hemodynamics; human disease; hypertensive heart disease; pressure

Core B will have three functions. First, Core B will provide the production of the animal models used in Project 2 (renal wrapping induced hypertension in dogs) and Project 3 (rapid ventricular pacing model of progressive heart failure). Second, Core B will provide high quality echocardiographic assessment of ventricular structure and function in humans and in experimental models of human disease in each of the four Projects (mouse and dog). Finally Core B will provide standardized invasive hemodynamic assessment of ventricular structure and function including simultaneous analysis of pressure and volume in transgenic mice and in canine models of systolic heart failure and hypertensive heart disease.

核心B将具有三个功能。首先，核心B将提供项目2（肾包裹诱发的狗高血压）和项目3（进行性心力衰竭的快速心室起搏模型）中使用的动物模型的制作。其次，核心 B 将为四个项目（小鼠和狗）中的每个项目以及人类疾病实验模型中的心室结构和功能提供高质量的超声心动图评估。最后，Core B 将提供心室结构和功能的标准化侵入性血流动力学评估，包括同步分析转基因小鼠以及收缩性心力衰竭和高血压心脏病的犬模型中的压力和容量。