Molecular Epidemiology of Non-Melanoma Skin Cancer

非黑色素瘤皮肤癌的分子流行病学

基本信息

批准号：
7851050
负责人：
HEATHER Hammond NELSON
金额：
$ 41.81万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-09-30 至 2012-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7851050
关键词：
Address Autoimmune Diseases Basal cell carcinoma Biological Models Cancer Etiology Candidate Disease Gene Case-Control Studies Caucasians Caucasoid Race DNA DNA Repair Gene Data Discipline Disease Drug Metabolic Detoxication Epidemiologic Studies Estrogens Genes Genetic Polymorphism Genetic Predisposition to Disease Genetic Variation Genotype Glucocorticoids Grant Health Human Papillomavirus IL12B gene IL4 gene IL4R gene IL6 gene Immune Immune Targeting Immunity Immunosuppression Infection Inflammation Interleukin-10 Malignant Neoplasms Metric Molecular Epidemiology New Hampshire Oxidative Stress PTGS2 gene Pathway interactions Play Predisposition Principal Investigator Process Recording of previous events Resources Risk Role Sampling Signal Pathway Signal Transduction Single Nucleotide Polymorphism Skin Cancer Skin Carcinoma Squamous cell carcinoma Sum Sun Exposure TNF gene TNFRSF1B gene Testing Ultraviolet Rays Vaccines Work carcinogenesis gene environment interaction genetic variant novel population based public health relevance skin cancer prevention vaccine development

项目摘要

DESCRIPTION (provided by applicant): Non-melanoma skin cancers (NMSC) are the most prevalent malignancies among Caucasians. Further, skin cancer is a model system for understanding carcinogenesis and genetic susceptibility to environmentally-induced cancers. Our prior work on genetic susceptibility has focused on mutagenicity pathways, testing hypotheses regarding polymorphisms in DNA repair genes and genes in oxidative stress detoxification. Moving forward, we will continue to build on the tremendous existing resource of a large population-based case control study in New Hampshire (approximately 1500 basal cell carcinoma (BCC), 1200 squamous cell carcinoma (SCC) and 1400 controls, principal investigator: Karagas, CA57494). In this new grant period we will shift our focus to alternative pathways of susceptibility in NMSC, focusing on the role of immune signaling. Ultraviolet radiation (UV) is well documented to induce local and systemic immunosuppression. We will address genetic susceptibility to NMSC targeting immune signaling and inflammation pathways. These findings will be directly translatable to other cancers and disease processes. This application aims to identify genetic variation in immune signaling pathways that enhances susceptibility to skin cancer. Identified genes would be useful in understanding skin cancer prevention, as well as other diseases with a strong immune component (i.e. autoimmune disease and vaccine efficiency). PUBLIC HEALTH RELEVANCE: Ultraviolet radiation (UV) is well documented to induce local and systemic immunosuppression. This application aims to identify genetic variation in immune signaling pathways that enhances susceptibility to skin cancer. Identified genes would be useful in understanding skin cancer prevention, as well as other diseases with a strong immune component

描述（由申请人提供）：非黑色素瘤皮肤癌（NMSC）是高加索人中最普遍的恶性肿瘤。此外，皮肤癌是一种模型系统，用于了解对环境诱导的癌症的癌变和遗传敏感性。我们先前关于遗传易感性的工作集中在诱变途径上，测试了关于DNA修复基因多态性的假设以及氧化应激排毒中的基因。展望未来，我们将继续基于新罕布什尔州大型基于人群的案例控制研究的巨大资源（大约1500个基底细胞癌（BCC），1200个鳞状细胞癌（SCC）和1400个对照组，主要研究者：Karagas：Karagas，CA57494）。在这个新的赠款期间，我们将把重点转移到NMSC中敏感性的替代途径，重点是免疫信号传导的作用。紫外线辐射（UV）已充分记录在诱导局部和全身免疫抑制。我们将解决对NMSC靶向免疫信号传导和炎症途径的遗传敏感性。这些发现将直接转化为其他癌症和疾病过程。该应用旨在确定免疫信号通路的遗传变异，从而增强对皮肤癌的敏感性。鉴定的基因将有助于了解预防皮肤癌，以及其他具有较强免疫成分（即自身免疫性疾病和疫苗效率）的疾病。公共卫生相关性：紫外线辐射（UV）已充分记录在局部和全身免疫抑制。该应用旨在确定免疫信号通路的遗传变异，从而增强对皮肤癌的敏感性。鉴定的基因将有助于理解预防皮肤癌，以及其他具有较强免疫成分的疾病