Novel Mouse Models to Study ERK 1/2 Regulated Genes In Vivo

用于研究体内 ERK 1/2 调控基因的新型小鼠模型

基本信息

批准号：
7751568
负责人：
Heng-Yu Fan
金额：
$ 5.72万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2010-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7751568
关键词：
Address Adenovirus Vector Adenylate Cyclase Biochemical CCAAT-Enhancer-Binding Protein-alpha CCAAT-Enhancer-Binding Protein-beta CCAAT-Enhancer-Binding Proteins Cell Cycle Arrest Cell Cycle Progression Cell physiology Cells Communication Cyclic AMP Cyclic AMP-Dependent Protein Kinases Data Development Event Exhibits Follicle Stimulating Hormone Receptor Frequencies G-Protein-Coupled Receptors Gene Targeting Genes Growth Human Infertility KRAS2 gene Knockout Mice LH Receptors Ligand Binding Link Luteinization Mediating Mitogen-Activated Protein Kinase 3 Modeling Molecular Mutant Strains Mice Neonatal Oocytes Ovarian Ovarian Granulosa Cell Ovary Ovulation Pathway interactions Phenotype Phosphorylation Physiological Population Process Role Stream System base granulosa cell in vivo mouse model mutant mouse model novel remediation reproductive success selective expression senescence

项目摘要

DESCRIPTION (provided by applicant): There is a high frequency of infertility in human populations, much of it unexplained. It is certain that disruption of the ovulation process and the events of cumulus expansion and the communication between the cumulus and the oocyte are important causes of human infertility. This project will directly and efficiently study these processes in a mammalian model, and information pertinent to human infertility and its remediation is expected to emerge.

描述（由申请人提供）：人口中的不育频率很高，其中大部分无法解释。可以肯定的是，排卵过程的破坏以及积云扩张的事件以及积云和卵母细胞之间的交流是人类不育症的重要原因。该项目将在哺乳动物模型中直接有效地研究这些过程，并且与人类不孕症有关的信息及其补救症有望出现。