Regenerative Sciences Training Program(RMI)

再生科学培训计划(RMI)

• 批准号: 7122090
• 负责人: Steven A Goldstein
• 金额: $ 52.84万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7122090
• 关键词: Chordata; NIH Roadmap Initiative tag; bioengineering /biomedical engineering; biological signal transduction; biomaterial development /preparation; biomechanics; clinical research; computational biology; cooperative study; education evaluation /planning; extracellular matrix; health science research potential; histogenesis; interdisciplinary collaboration; medical education; model design /development; musculoskeletal system; physical model; postdoctoral investigator; predoctoral investigator; regeneration; science education; structural biology; training

DESCRIPTION (provided by applicant): This proposal seeks support for the development of a new interdisciplinary training program in Regenerative Science. Repair or regeneration of tissues can be characterized as a symphony of cellular activities often beginning with an acute inflammatory response followed by granulation tissue infiltration, recruitment, proliferation and differentiation of progenitor cells, matrix formation and organization, and eventual remodeling. The process occurs within the context of biologic and mechanical signals. While many scientists, engineers and clinicians working across numerous disciplines are dedicated to advancing the repair or regeneration of tissues and organs, they fall short in their ability to communicate, interpret, or integrate across the many core competencies that we believe are required to make substantial advances in regenerative medicine. These core competencies include: developmental biology, extracellular matrix structure and organization, bioregulatory signaling, tissue structure and function, preclinical models development, structural and computational modeling, clinical research design principles, and commercialization and regulatory parameters. This program will admit biologists, engineers and clinicians with training depth in one or more disciplines and augment their abilities by teaching them critical aspects of these core competencies through didactic and research intensive experiences. While this training program will expand to train in all organ or tissue systems in the future, its initial training will focus on musculoskeletal tissues.

描述（由申请人提供）： 该提案寻求支持开发新的再生科学跨学科培训计划。组织的修复或再生可被描述为细胞活动的交响乐，通常以急性炎症反应开始，随后是肉芽组织浸润、祖细胞募集、增殖和分化、基质形成和组织以及最终重塑。该过程发生在生物和机械信号的背景下。尽管许多跨学科工作的科学家、工程师和临床医生致力于促进组织和器官的修复或再生，但他们缺乏沟通、解释或整合许多核心能力的能力，我们认为这些核心能力是实现实质性目标所必需的。再生医学的进展。这些核心能力包括：发育生物学、细胞外基质结构和组织、生物调节信号传导、组织结构和功能、临床前模型开发、结构和计算建模、临床研究设计原则以及商业化和监管参数。该项目将招收在一个或多个学科中接受过深度培训的生物学家、工程师和临床医生，并通过教学和研究密集型经验教授他们这些核心能力的关键方面，从而增强他们的能力。虽然该培训计划未来将扩展到所有器官或组织系统的培训，但其最初的培训将侧重于肌肉骨骼组织。