Gammacell-40 Exactor Research Irradiator

Gammacell-40 Exactor 研究辐照器

• 批准号: 7212058
• 负责人: PHILLIP SCOTT
• 金额: $ 40.74万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-08 至 2008-06-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7212058
• 关键词: Animal Experimentation; Animals; Area; Arts; Bone Marrow; Chimera organism; Commit; Contract Services; Dose-Rate; Faculty; Funding; Funding Applicant; Housing; Immune response; Immunologic Deficiency Syndromes; Individual; Laboratories; Laboratory Research; Maintenance; Modeling; Mus; Pennsylvania; Research; Research Personnel; Rodent; Schools; Security; Services; Stem cells; Universities; Veterinary Medicine; Veterinary Schools; Wages; animal facility; base; day; design; human disease; instrument; irradiation; medical schools; pathogen; programs; reconstitution; research study; tumor

DESCRIPTION (provided by applicant): Funds are requested for a MDS Nordian Inc. Gammacell-40 Exactor Self-contained Low Dose Rate Research animal (rodent) irradiator to support the ongoing NIH-funded individual-initiated research programs in a new state of the art animal facility located within a recently erected research building (Hill Pavilion) on the campus of the University of Pennsylvania School of Veterinary Medicine. Ten core laboratories comprise the list of the major users of the requested instrument. Each will have laboratories in either the Hill Pavilion or the adjacent research laboratories at the Penn Vet School and all of them will house their mice and perform ongoing experiments requiring whole animal irradiation and extended maintenance of irradiated animals in ongoing experiments in the animal facility in the Hill Pavilion. These core laboratories will constitute the majority (>70%) of the usage of the irradiator by the School of Veterinary Medicine. There is a group of additional Veterinary School faculty that will utilize this instrument on an infrequent (<5%) basis. In addition, since the vivarium in Hill will be shared with the School of Medicine, there will be substantial usage by NIH-funded faculty from University of Pennsylvania School of Medicine who will occupy part of the new animal facility in the Hill Pavilion (25%). A specific need for this instrument arises because the new animal facility in which the animals of the core user group are housed is a closed facility in which animals taken to other buildings for irradiation cannot be returned to the investigator's designed area. As a consequence, it is impossible to perform long-term experiments requiring maintaining the animals beyond a single day after irradiation, or that require comparison of irradiated and non-irradiated experimental groups. As detailed in the project descriptions, these include irradiated, auto-reconstituting models, bone marrow chimeras, induction of immunodeficiency, among others. The University of Pennsylvania School of Veterinary Medicine has already made a significant financial commitment to support the procurement of this instrument, by constructing the room in which the irradiator will be housed. In addition, the School has committed funds for the ongoing service contract to maintain and service the instrument, and will provide salary support for a supervisor. The University will provide support for security. The installation of the Gammacell-40 in the Hill Pavilion vivarium will make possible studies that will elucidate immune responses to pathogens and tumors, as well as studies of stem cells. Each of these will advance our understanding of human diseases.

描述（由申请人提供）：需要为 MDS Nordian Inc. Gammacell-40 Exactor 自给式低剂量率研究动物（啮齿动物）辐照器提供资金，以支持正在进行的 NIH 资助的个人发起的研究项目。艺术动物设施位于宾夕法尼亚大学兽医学院校园内最近建成的研究大楼（Hill Pavilion）内。十个核心实验室组成了所请求仪器的主要用户列表。每个实验室都将在 Hill Pavilion 或宾夕法尼亚州兽医学校的邻近研究实验室中设有实验室，所有这些实验室都将饲养小鼠并进行正在进行的实验，需要对整个动物进行照射，并在宾夕法尼亚州动物设施中进行的正在进行的实验中对受照射的动物进行长期维护。山亭。这些核心实验室将占兽医学院辐照器使用量的大部分（>70%）。还有一组额外的兽医学院教员将不经常（<5%）使用该仪器。此外，由于 Hill 的动物饲养场将与医学院共享，因此宾夕法尼亚大学医学院的 NIH 资助教师将大量使用，他们将占用 Hill Pavilion 新动物设施的一部分（25% ）。对这种仪器的特殊需求是因为饲养核心用户组动物的新动物设施是封闭设施，被带到其他建筑物进行照射的动物不能返回研究者设计的区域。因此，不可能进行需要在照射后维持动物超过一天的长期实验，或者需要对照射和未照射的实验组进行比较的长期实验。正如项目描述中所详述的，这些包括辐照、自动重建模型、骨髓嵌合体、免疫缺陷诱导等。宾夕法尼亚大学兽医学院已经做出了重大财务承诺，通过建造放置辐照器的房间来支持该仪器的采购。此外，学校还承诺为持续的服务合同提供资金，以维护和维修仪器，并将为主管提供薪资支持。大学将提供安全支持。 Hill Pavilion 动物园中安装的 Gammacell-40 将使阐明对病原体和肿瘤的免疫反应的研究以及干细胞的研究成为可能。这些都将增进我们对人类疾病的理解。