Neurobehavioral Effects of Insecticide Exposure in Pregnancy and Early Childhood

怀孕和幼儿期接触杀虫剂对神经行为的影响

• 批准号: 7372763
• 负责人: KIMBERLY YOLTON
• 金额: $ 75.09万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-19 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7372763
• 关键词: 3 year old; Adult; Age; Air; Alcohol consumption; Animal Experimentation; Animals; Attention; Behavior; Behavior assessment; Behavioral; Biological; Biological Markers; Biological Markers; Birth; Blood; Brain; Breathing; Case Series; Characteristics; Child; Childhood; Chronic; Cognition; Cognitive; Cohort Studies; Collection; Complex; Data; Data Collection; Data Quality; Dermal; Development; Dietary Practices; Dose; Enrollment; Environmental Health; Epidemiologic Studies; Evaluation; Exposure to; Fetal Development; Fetus; Fingers; Floor; Food; Funding; Goals; Hand; Health; Home environment; Home visitation; Hour; House Call; Household; Human; Infant; Ingestion; Insecta; Insecticides; Intake; Intelligence; Laboratories; Language; Lead; Life; Link; Measurement; Measures; Meconium; Modeling; Mothers; Motor; Motor Skills; Neonatal Intensive Care Units; Nervous System Physiology; Neurologic; Neurotoxins; Newborn Infant; Oral cavity; Organophosphates; Outcome; Outcome Measure; Pest Control; Pesticides; Pharmaceutical Preparations; Physiology; Placenta; Pregnancy; Pregnancy Outcome; Pregnant Women; Problem behavior; Procedures; Prospective Studies; Research Design; Research Infrastructure; Sampling; Socioeconomic Status; Source; Staging; Surface; Techniques; Testing; Time; Toxic Environmental Substances; Toxic effect; United States National Institutes of Health; Urine; Visit; Water; Weight; absorption; cohort; design; developmental neurotoxicity; early childhood; executive function; follow-up; infancy; innovation; neonate; neurobehavior; neurobehavioral; neurobehavioral test; neurotoxic; postnatal; prenatal; prenatal exposure; pyrethroid; tobacco exposure; tool; visual-motor integration

DESCRIPTION (provided by applicant): The objective of this study is to examine the effects of exposure to prevalent insecticides on neurobehavioral outcomes in a cohort of 399 children. We will include an evaluation of prenatal exposure effects observed during the newborn period, as well as postnatal exposure effects through age six. Children are currently enrolled in cohort study investigating the health, developmental, and behavioral consequences of exposure to a variety of environmental toxicants and with planned follow-up to age two. Original funding was through NIEHS/EPA. Biological samples will be used to assess exposure to insecticides prenatally (maternal urine, infant meconium) and postnatally (child urine). We will examine newborn neurobehavioral outcomes within the first 36 hours of life and during a home visit at 4 weeks, using the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS), to assess the earliest effects of prenatal exposure to prevalent insecticides. The study will extend follow-up of this cohort to include assessments or development, cognition, motor skills, and behaviors at ages 4, 5, and 6 in an effort to examine the effects of postnatal exposure to insecticides. Analyses will employ multivariate and causal modeling techniques. Potential covariates will include maternal drug and alcohol use during pregnancy, pregnancy outcomes and infant characteristics, maternal characteristics and qualities of the home environment, socioeconomic status variables, lead and tobacco exposure, and other variables as appropriate. Data from biological samples and neurobehavioral testing collected at earlier visits will also be available. We propose the following aims: AIM 1 To characterize the association of prenatal exposure to prevalent insecticides, as determined by biomarkers collected in maternal urine during pregnancy and in meconium shortly after birth, with neurobehavior during the newborn period measured with the NNNS. Aim 2 To characterize the association of postnatal exposure to prevalent insecticides, as determined by measures of insecticides in child urine with neurobehavior at ages four to six years. We will carefully examine the effects of prenatal and postnatal exposure to prevalent insecticides using multiple biological markers of exposure at numerous time points and sensitive neurobehavioral assessment tools from the newborn period through age five years. This study offers a unique opportunity to examine the early effects of prenatal and postnatal exposure to insecticides on neurobehavioral outcomes in a trajectory from the newborn period through age six years, while utilizing the research infrastructure of an established cohort study.

描述（由申请人提供）：这项研究的目的是检查暴露于399名儿童队列中神经行为结果的暴露对神经行为结果的影响。我们将包括对新生儿期间观察到的产前暴露效应的评估，以及六岁的产后暴露效应。目前，儿童正在参加研究，研究了暴露于各种环境有毒物质以及计划对两岁的随访的健康，发育和行为后果。原始资金是通过NIEHS/EPA。生物样品将用于评估产前（母尿，婴儿胎粪）和产后（儿童尿液）的杀虫剂的暴露。我们将在生命的最初36个小时内检查新生儿神经行为结局，并在4周的家庭访问中使用新生儿重症监护室网络Neurobehaviorhavioral量表（NNNS）评估产前暴露于普遍杀虫剂的最早影响。这项研究将扩展该队列的随访，包括4、5和6岁的评估或发展，认知，运动技能和行为，以研究产后暴露于杀虫剂的影响。分析将采用多元和因果建模技术。潜在的协变量将包括怀孕期间的孕产妇药物和饮酒，怀孕结果和婴儿特征，家庭环境的母体特征和质量，社会经济状况变量，铅和烟草暴露以及其他适当的变量。还将提供来自生物样品和在较早访问时收集的神经行为测试的数据。我们提出以下目的：目标1旨在表征产前暴露与普遍杀虫剂的缔合，如怀孕期间在母体尿液中收集的生物标志物和出生后不久的胎粪所确定的，在新生儿期间与NNNS测量的新生儿期间的神经行为。目的2是为了表征产后与普遍杀虫剂的关联，这取决于四到六岁的儿童尿液中杀虫剂与神经行为的措施确定。我们将仔细检查产前和产后暴露于普遍的杀虫剂的影响，使用多种生物学标记在许多时间点暴露，以及从新生儿到五岁的新生儿时期的敏感神经行为评估工具。这项研究提供了一个独特的机会，可以检查产前和产后暴露于杀虫剂对新生儿时期至六岁的轨迹中神经行为结局的早期影响，同时利用一项既定的同类研究的研究基础设施。