HYBRIDOMA CORE

杂交瘤核心

• 批准号: 7529368
• 负责人: CLEMENCIA COLMENARES
• 金额: $ 4.37万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-06 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7529368
• 关键词: Antigens; Cell Death; Cell Differentiation process; Clinic; Communities; Core Facility; Goals; Hybridomas; Mission; Modification; Monoclonal Antibodies; Numbers; Operative Surgical Procedures; Post-Translational Protein Processing; Proteins; Research; Research Institute; Research Personnel; Resources; Services; Signaling Protein; Tissues; Tumor Suppressor Genes; anticancer research; cell growth; cost; intracellular protein transport; novel; protein localization location; tool

The goal of the Hybridoma Core is to provide a cost-effective resource for generating monoclonal antibodies to novel antigens that will enable investigators to discriminate among the proteins relevant to their research. Highly specific monoclonal antibodies are an essential resource in identifying the levels of expression, specific modifications, and tissue localization of proteins involved in all the functions that control cell growth, cell differentiation, and cell death. Monoclonals have provided, and will continue to provide, critical tools in all aspects of cancer research that involve specific proteins, including signaling proteins, oncogenes, and tumor suppressors. The Hybridoma Core Facility is an efficient operation with a staff of 2 FTEs located at the Cleveland Clinic's Lerner Research Institute. The core already provides services to investigators at Case, and indeed to all of the Cleveland scientific community, as well as to some outside users, both academic and for-profit. The core attempts to make its services both cost-effective and customizable, in order to benefit the largest possible number of investigators.

杂交瘤核心的目的是提供一种具有成本效益的资源来产生单克隆抗体 将研究人员歧视与其研究相关的蛋白质之间的新型抗原。 高度特定的单克隆抗体是确定表达水平的重要资源， 参与控制细胞生长的所有功能的蛋白质的特定修饰和组织定位， 细胞分化和细胞死亡。单克隆人已经提供并将继续提供关键工具 涉及特定蛋白质的癌症研究的所有方面，包括信号蛋白，癌症和 肿瘤抑制剂。杂交瘤核心设施是一个有效的运营 克利夫兰诊所的勒纳研究所。核心已经为调查人员提供服务 案例，甚至是克利夫兰的所有科学界，以及一些外部用户 学术和营利性。核心试图使其服务具有成本效益且可自定义， 为了使最大数量的调查人员受益。