Research Programs-Cancer Genetics

研究项目-癌症遗传学

基本信息

批准号：
7513238
负责人：
Allen Everett Bale
金额：
$ 1.6万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-08-09 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7513238
关键词：
APC gene Accounting Adenomatous Polyposis Coli Adult Animal Model Basal Cell Nevus Syndrome Basal cell carcinoma Base Sequence Basic Science Biological CDKN2A gene Cancer Family Carcinogen Metabolism Carcinogenesis Mechanism Caring Cells Charge Chemopreventive Agent Clinical Clinical Data Clinical Management Clinical Research Collaborations Colon Carcinoma Core Facility Counseling CpCp DNA Repair Defect Diagnosis Direct Costs Discipline of obstetrics Disease Management Drosophila genus Environmental Carcinogens Environmental Risk Factor Epidemiologist Epidemiology Epigenetic Process Event Faculty Frequencies Funding Gene Expression Regulation Gene Mutation Genes Genetic Genetic Counseling Genetic Polymorphism Genetic Predisposition to Disease Genetic Programming Genetic Variation Genomics Germ-Line Mutation Goals Growth Gynecology Health Services Research Hereditary Disease Hereditary Malignant Neoplasm Hereditary Melanoma Immune Individual Inherited Joints Laboratories Laboratory Scientists Leadership Link Maintenance Malignant Childhood Neoplasm Malignant Neoplasms Methods Mismatch Repair Molecular Mutate Mutation Neoplasms Oncogenes Operative Surgical Procedures Ovarian PTCH gene Patients Peer Review Pharmaceutical Preparations Phase I Clinical Trials Play Population Predisposition Prevalence Prevention Primary Health Care Professional counselor Publishing Regulation Relative Risks Reproduction spores Research Research Personnel Resource Sharing Retinoblastoma Risk Risk Factors Role Scientist Seeds Services Signal Transduction Pathway Skin Skin Cancer Specimen Sun Exposure Susceptibility Gene TNFRSF5 gene Testing Therapeutic Radiology specialty Work base cancer genetics cancer prevention cancer risk cancer therapy cancer type cell growth cost drug development environmental agent functional genomics gene cloning gene function genetic variant improved insight interest melanoma member novel oncology polyposis programs research study size skin color tool trait tumor

项目摘要

The Cancer Genetics Program (CGP) was founded in 1995 as a developing program, with the YCC providing seed money to hire a genetic counselor, initiate a coordinated clinical and research endeavor, and fund a portion of the Program Leader's effort. In 1996, a supplement was obtained to initiate a core facility for acquiring clinical data and biological specimens from cancer families. Under the leadership of Dr. Alan Bale, the Program has nearly doubled in size since its inception, and now includes 17 faculty members representing 8 departments. Cancer Genetic Counseling has grown to include 4 counselors and now functions as a Shared Resource, providing counseling services for research studies as well as for clinical support. The central themes of this program are identification of genes underlying hereditary cancer predisposition, studying the role of these genes in sporadic cancer, elucidating gene function, and applying novel research findings to diagnosis, disease management, and rational drug development. An example of the type of research this program supports is cloning the gene for the basal cell nevus syndrome (BCNS), elucidating the function of the gene using Drosophila as a model organism, and conducting an NCI-supported, phase I clinical trial using a drug specifically targeting this key molecular defect in skin cancer. The same strategy is being applied to a variety of other malignancies. The Program thus serves as a bridge between the Cancer Prevention & Control Program >(CPCP) and the Gene Regulation & Functional Genomics Program (GRFGP). While our Program members use molecular tools to identify and characterize the function of genes that is responsible for hereditary predisposition to cancer, GRFGP is charged with characterizing the genetic and epigenetic changes in sporadic tumors. Since many of the same genes play a role in both sporadic and hereditary cancer, discoveries by members of either program have clear relevance to the other. A new joint project of these two programs is microarray-based sequencing of all cancer predisposition genes. Together with CPCP, our Members also participate in efforts to examine the interplay of environmental and genetic factors in cancer risk, notably ovarian and skin cancer. The skin cancer work is part of a P50 SPORE relating common genetic variants of skin color and environmental risk factors. The Program members research funding over the past year include totaling $4.7 million direct costs ($6.67 million total costs) of which $1.2 million direct costs ($1.7 million total costs) is from the NCI. Over the past 7 years, the Program has published over peer-reviewed 164 articles of which approximately 39% resulted from interprogrammatic collaboration and 9.1% resulted from intraprogrammatic collaboration.

癌症遗传学计划 (CGP) 成立于 1995 年，是一个发展中的计划，由 YCC 提供种子资金聘请遗传咨询师，启动协调的临床和研究工作，并资助一部分项目负责人的努力。 1996年，获得了一项补充，启动了一个获取临床数据的核心设施。来自癌症家族的数据和生物样本。在艾伦·贝尔博士的领导下，该计划已自成立以来规模几乎增加了一倍，目前包括代表 8 个系的 17 名教职人员。癌症遗传咨询已发展到包括 4 名咨询师，现在作为共享资源，为研究和临床支持提供咨询服务。本次活动的中心主题计划是识别遗传性癌症易感性的基因，研究这些基因的作用在散发性癌症中，阐明基因功能，并将新的研究成果应用于诊断、疾病管理和合理的药物开发。该计划支持的研究类型的一个例子是克隆基底细胞痣综合征 (BCNS) 的基因，以果蝇为实验对象阐明了该基因的功能模型生物，并使用专门针对此关键的药物进行 NCI 支持的 I 期临床试验皮肤癌的分子缺陷。同样的策略也适用于各种其他恶性肿瘤。这因此，该计划成为癌症预防与控制计划 (CPCP) 和基因计划之间的桥梁。调控与功能基因组学计划 (GRFGP)。虽然我们的计划成员使用分子工具识别和表征导致癌症遗传易感性的基因的功能，GRFGP 负责表征散发性肿瘤的遗传和表观遗传变化。由于很多相同基因在散发性癌症和遗传性癌症中都发挥着作用，这两个项目的成员的发现都明确表明与对方的相关性。这两个项目的一个新联合项目是对所有癌症进行基于微阵列的测序易感基因。我们的会员还与 CPCP 一起参与研究各种因素之间的相互作用。环境和遗传因素影响癌症风险，尤其是卵巢癌和皮肤癌。皮肤癌工作是其中的一部分 a P50 SPORE 涉及肤色的常见遗传变异和环境风险因素。该计划成员过去一年的研究经费包括总计 470 万美元的直接费用（667 万美元总成本），其中 120 万美元直接成本（170 万美元总成本）来自 NCI。过去 7 年里，该计划已发表超过 164 篇经过同行评审的文章，其中约 39% 来自计划间合作，9.1% 来自计划内合作。