THE MULTIPLE ENDOCRINE NEOPLASIA TYPE I (MEN1) TUMOR SUPPRESSOR

I 型多发性内分泌肿瘤 (MEN1) 肿瘤抑制剂

• 批准号: 7721192
• 负责人: NIKOLA P PAVLETICH
• 金额: $ 0.97万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-15 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721192
• 关键词: Biochemical; Computer Retrieval of Information on Scientific Projects Database; Data; Disease; Endocrine; Endocrine Gland Neoplasms; Funding; Genetic; Grant; Growth; Institution; Link; Malignant Neoplasms; Menin; Mutation; NF-kappa B; Neoplasms; Numbers; Research; Research Personnel; Resources; Role; Source; Tissues; Tumor Suppressor Proteins; United States National Institutes of Health; transcription factor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Multiple Endocrine Neoplasia Type (MEN) is an automsomal dominant malignancy that is characterized by tumors of endocrine tissues. The genetic mechanism responsible for this malignancy has been linked to mutations of the Menin tumor suppressor. Despite the wealth of genetic data that support Menin?s role in MEN1 disease, the biochemical function of Menin is still unknown. However, recent studies have demonstrated that the tumor suppressor function of Menin resides in its ability to repress the transcriptional activity of a number of growth-promoting transcription factors, including JunD, Smad3 and NF-kB.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 多发性内分泌肿瘤型（MEN）是一种常染色体显性遗传恶性肿瘤，以内分泌组织肿瘤为特征。 导致这种恶性肿瘤的遗传机制与 Menin 肿瘤抑制基因的突变有关。尽管有大量的遗传数据支持 Menin 在 MEN1 疾病中的作用，但 Menin 的生化功能仍然未知。 然而，最近的研究表明，Menin的抑癌功能在于其能够抑制多种促生长转录因子的转录活性，包括JunD、Smad3和NF-kB。