MODELLING HIPPOCAMPUS SUB-STRUCTURES

海马子结构建模

• 批准号: 7724432
• 负责人: SYLVAIN BAILLET
• 金额: $ 0.26万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724432
• 关键词: Amygdaloid structure; Bite; Brain; Clinical; Complex; Computer Retrieval of Information on Scientific Projects Database; Cryoultramicrotomy; Data; Databases; Depth; Epilepsy; Funding; Generic Drugs; Grant; Hippocampus (Brain); Human; Implant; Individual; Institution; Label; Magnetic Resonance Imaging; Modeling; Paper; Patients; Research; Research Personnel; Resolution; Resources; Running; Source; Structure; Thinking; United States National Institutes of Health; design; interest; reconstruction; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our group has recently developed some segmentation tools dedicated to the hippocampus-amygdala complex in TLE and AD patients from basic clinical MR images (Chupin et al., ISBI2002). We're interested in detecting these deeper structures using MEG. Recent data we've acquired with implanted epileptic patients recorded simultaneously in MEG indicate this is very promising. Our tools run some automatic segmentation of the hippocampus and amygdala envelopes. Now we would like to develop generic models of the hippocampus detailed inner structure. Our idea is to obtain a 3D template of the hippocampus, with labelled sub-structures, that we would deform and warp to the individual envelope we would extract from individual MRs. We came accross Prof Toga's 1994 and 1997 papers dealing with the cryosectioned human brains and thought part of the data you've been using could be of great interest to us. We could precisely delineate manually the structures we are interested in (Hippocampus, Amygdala and adjacent cortices, things that are already described in the 1997 paper) and push this a bit further by labelling some sub-structures of interest with the help of our neuroanatomist expert. 3D tessellated models could be designed together with the overall envelope obtained from our segmentation tool. These objects would become a 3D template that could be warped to the individual envelope extracted from an MR scan.This collaborative project with LONI requires we gain access to the high-resolution pictures of one of the cryosectioned brains and of its 3D reconstruction in LONI's database.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们的小组最近开发了一些分割工具，该工具专门针对TLE的海马 - 杏仁核复合物和基本临床MR图像的AD患者（Chupin等，ISBI2002）。我们有兴趣使用MEG检测这些更深的结构。我们最近在MEG中同时记录的植入癫痫患者获得的最新数据表明，这是非常有前途的。我们的工具对海马和杏仁核信封进行了一些自动分割。现在，我们想开发海马详细内部结构的通用模型。我们的想法是获得带有标记的子结构的海马的3D模板，我们将变形并转向我们将从各个MRS中提取的单个信封。我们来了托加教授的1994年和1997年涉及冷冻人类大脑的论文，您一直使用的数据的一部分可能引起了我们的兴趣。我们可以精确地描述我们感兴趣的结构（海马，杏仁核和相邻的皮层，这是1997年论文中已经描述的东西），并通过在我们的Neuroanatomist专家的帮助下标记一些感兴趣的子结构来进一步推动这一点。 3D镶嵌模型可以与我们的分割工具获得的整体信封一起设计。这些对象将成为一个3D模板，可以扭曲为从MR扫描中提取的单个信封。与LONI的合作项目需要我们访问Croyectioned Brains的高分辨率图片及其在LONI数据库中的3D重建。