3rd ASM Conference on Cell-Cell Communication in Bacteria

第三届 ASM 细菌细胞间通讯会议

基本信息

批准号：
7334081
负责人：
WILLIAM C FUQUA
金额：
$ 1万
依托单位：
AMERICAN SOCIETY FOR MICROBIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-01 至 2008-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7334081
关键词：
Antibiotics Area Bacteria Bacterial Adhesins Behavior Bioluminescence Cell Communication Cell physiology Cells Chemicals Collaborations Commit Communicable Diseases Communication Communities Competence Condition Disease Environment Enzymes Exhibits Funding Genetic Goals Health Horizontal Gene Transfer Human Immune response Infectious Agent International Life Location Mediating Microbe Microbial Biofilms Microbiology Monitor National Institute of General Medical Sciences Numbers Oligopeptides Participant Pathogenesis Perception Population Population Density Process Production Pseudomonas aeruginosa Public Health Purpose Range Reliance Reporting Research Scientist Signal Transduction Staphylococcus aureus Streptococcus pneumoniae System Texas Time Tissues Toxin United States National Institutes of Health Vibrio fischeri Virulence Virulence Factors Work austin clay coping exoenzyme homoserine lactone improved microbial microorganism pathogen prevent quorum sensing response symposium trend

项目摘要

DESCRIPTION: ASM Conference on Cell-Cell Communication in Bacteria, Clay Fuqua and Heidi B. Kaplan, Co-Organizers. Bacteria are the paradigm for unicellular life, yet they also exhibit elaborate coordinated behaviors that often defy unicellularity. Single bacterial cells respond to their immediate physical and chemical environment, adapting in response to changing conditions. In the 1960s and 1970s several reports suggested that bacteria might communicate with each other via chemical signals, specifically in regulating genetic competence in Streptococcus pneumoniae and in controlling bioluminescence in Vibrio fischeri, respectively. Research over the past decade has begun to reveal that a wide range of bacteria can communicate by diverse mechanisms. In most cases these microbial conversations occur through the exchange of diffusible signals, although there are also clear examples of cell contact-dependent communication. Many bacteria use these signaling mechanisms to monitor and respond to population density, a process often described as quorum sensing. Interbacterial communication is not however restricted to quorum sensing mechanisms and there is mounting evidence that signaling can function in a range of different capacities. Communication between microorganisms can have profound impacts on human health, as pathogens and commensals often regulate important aspects of their host interactions using signal production and perception. Target functions include, but are not restricted to virulence factors, adhesins, biofilm formation, horizontal gene transfer and the secretion of exoenzymes. Well established systems such as the cyclic oligopeptide signals that regulate Staphylococcus aureus virulence and acyl homoserine lactones (AHLs) that control of pathogenesis in Pseudomonas aeruginosa are now joined by a number of more recently identified signaling systems. The range and diversity of these systems continues to grow explosively. Due to the rapid pace of discovery in this area of microbiology and the excitement it has generated, the ASM has hosted two previous Cell-Cell Communication in Bacteria (CCCB) conferences, in 2001 and in 2004. Strong community support for a third conference led the ASM to commit to the current conference, to be held in Austin, Texas 2007. The goal of this conference is to act as a conduit for the exchange and synthesis and new ideas among leading US and international scientists working on communication. The past two conferences greatly stimulated the cell- cell communication community, led to outstanding discourse and productive new collaborations. A large number of the participants that attend this conference are funded through NIH, and the NIGMS has been generously supportive of the two previous two meetings. We are therefore hopeful that this trend continues for this important microbiology conference. Public Health Relevance Statement: The process of cell-cell communication in bacteria has tremendous impact on human health at several different levels. Pathogenic microorganisms that cause infectious disease in humans represent some of the most intensively studied examples of bacterial signaling. Coordination in the production of colonization factors, toxins, and tissue-damaging enzymes is often mediated through bacterial communication, whereby the infectious populations dictate the time, location and intensity of host damage, to best cope with the immune response. Advances in the understanding of how, why and when microbes employ signaling has great potential to improve our ability to combat infectious agents. New therapies directed towards microbial communication networks promise to augment and improve our current reliance on antibiotics, expanding our ability to treat and prevent disease, and manipulate bacterial behavior for beneficial purposes. The Cell-Cell Communication in Bacteria 2007 conference will gather together the best US and international scientists working in this area to exchange new information, ideas and strategies for targeting and harnessing the recently discovered communication mechanisms of microorganisms.

描述：ASM 细菌细胞间通讯会议，联合组织者 Clay Fuqua 和 Heidi B. Kaplan。细菌是单细胞生命的典范，但它们也表现出复杂的协调行为，这些行为往往与单细胞生命相悖。单个细菌细胞对其直接的物理和化学环境做出反应，以适应不断变化的条件。在 20 世纪 60 年代和 1970 年代，一些报告表明细菌可能通过化学信号相互交流，特别是分别在调节肺炎链球菌的遗传能力和控制费氏弧菌的生物发光方面。过去十年的研究已经开始表明，多种细菌可以通过不同的机制进行交流。在大多数情况下，这些微生物对话是通过可扩散信号的交换而发生的，尽管也有细胞接触依赖性通信的明显例子。许多细菌利用这些信号机制来监测和响应种群密度，这一过程通常被称为群体感应。然而，细菌间通讯并不限于群体感应机制，并且越来越多的证据表明信号传导可以以一系列不同的能力发挥作用。微生物之间的交流可以对人类健康产生深远的影响，因为病原体和共生体经常利用信号产生和感知来调节其宿主相互作用的重要方面。目标功能包括但不限于毒力因子、粘附素、生物膜形成、水平基因转移和外酶的分泌。一些成熟的系统，例如调节金黄色葡萄球菌毒力的环状寡肽信号和控制铜绿假单胞菌发病机制的酰基高丝氨酸内酯（AHL），现在与许多最近发现的信号系统结合在一起。这些系统的范围和多样性继续呈爆炸式增长。由于微生物学领域的快速发现及其所产生的兴奋，ASM 于 2001 年和 2004 年主办了两届细菌细胞间通讯 (CCCB) 会议。第三次会议得到了社区的大力支持ASM 承诺参加将于 2007 年在德克萨斯州奥斯汀举行的本次会议。本次会议的目标是成为美国和国际领先科学家之间进行交流、综合和新思想的渠道。过去的两次会议极大地刺激了细胞间通信界，带来了精彩的讨论和富有成效的新合作。参加本次会议的大量与会者均由 NIH 资助，NIGMS 也对前两次会议给予了慷慨支持。因此，我们希望这一重要的微生物学会议能够继续保持这种趋势。公共卫生相关性声明：细菌的细胞间通讯过程在多个不同层面对人类健康产生巨大影响。引起人类传染病的病原微生物是细菌信号传导研究最深入的一些例子。定植因子、毒素和组织损伤酶的产生的协调通常通过细菌通讯来介导，感染群体决定宿主损伤的时间、位置和强度，以最好地应对免疫反应。对微生物如何、为何以及何时使用信号传导的理解的进步，对于提高我们对抗传染源的能力具有巨大的潜力。针对微生物通讯网络的新疗法有望增强和改善我们目前对抗生素的依赖，扩大我们治疗和预防疾病以及操纵细菌行为以达到有益目的的能力。 2007 年细菌细胞间通讯会议将聚集该领域最优秀的美国和国际科学家，交流针对和利用最近发现的微生物通讯机制的新信息、想法和策略。