PROFILING OF CORTICAL AREAS BY MICRO-MRI

通过显微 MRI 分析皮质区域

• 批准号: 7726197
• 负责人: Jacopo Annese
• 金额: $ 0.65万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7726197
• 关键词: Area; Brain; Computer Retrieval of Information on Scientific Projects Database; Data; Funding; Goals; Grant; Human; Image; Individual; Institution; Magnetic Resonance Imaging; Maps; Microscopic; Relative (related person); Research; Research Personnel; Resources; Sampling; Scanning; Scheme; Source; Specimen; Surface; Thick; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of the study is to analyze the cortical mantle of the human brain systematically, according to Brodmann's parcellation scheme, in order to determine the microscopic MRI profiles of individual cortical areas. Small samples of cortex, acquired perpendicular to the cortical surface, will be imaged using established sequences available for the 9T magnet at Duke's CIVM. Micro-MRI signatures relative to specific architetconic features in each sample (layer thickness and cytological parameters) will be validated by subsequent quantitative histological analysis. Imaging data and quantitative information will be displayed onto an organized surface map of the cortex, derived from the scan of the whole original brain specimen.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该研究的目的是根据Brodmann的分析方案，系统地分析人脑的皮质披风，以确定单个皮质区域的微观MRI谱。垂直于皮质表面的皮质样品将使用可用于杜克Civm的9T磁铁的既定序列进行成像。相对于每个样品中特定架构特征（层厚度和细胞学参数），微MRI签名将通过随后的定量组织学分析来验证。成像数据和定量信息将显示在皮质的有组织的表面图上，该皮层的表面图源自整个原始脑标本的扫描。