Biomarkers of Exposure to Hazardous Substances

接触有害物质的生物标志物

基本信息

批准号：
7664695
负责人：
BRUCE D HAMMOCK
金额：
$ 7.6万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-04-01 至 2010-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7664695
关键词：
Activins Acute Address Adult Adverse effects Affect Air Algorithms Analytical Chemistry Animal Model Animals Antibodies Antioxidants Area Attention Automation Bacteria Basic Science Binding Biodegradation Bioinformatics Biological Biological Assay Biological Markers Biological Process Bioremediations Biosensor Breathing Budgets Burn injury Calcium Signaling California Carbon Cell physiology Cells Chemicals Chemistry Chronic Class Collaborations Communities Community based prevention Complex Mixtures Computer Simulation Consultations Coupled DNA DNA Microarray Chip DNA Microarray format Data Data Set Databases Detection Development Dioxins Disulfides Dose Down-Regulation Eating Ecology Electrodes Electrostatics Endocrine Endocrine Disruptors Engineering Environment Environmental Hazards Environmental Monitoring Environmental Pollution Enzymes Epidemiologist Epidemiology Epithelial Epithelial Cells Epithelium Europium Evaluation Experimental Designs Exposure to Female Film Future Gene Expression Gene Expression Profile Genes Genomics Goals Gold Grant Haptens Hazardous Chemicals Hazardous Substances Hazardous Waste Hazardous Waste Sites Health Health Services Heat shock proteins Heavy Metals Hormones Human Human Resources Immunoassay Immunological Diagnosis In Situ In Vitro Indium Individual Inflammation Information Technology Internet Intervention Studies Investigation Island Kidney Knowledge Label Laboratories Lanthanoid Series Elements Life Ligands Link Lipids Localized Lung Maintenance Measurement Measures Medical Surveillance Metabolic Activation Metals Methodology Methods Microbe Modeling Molecular Molecular Chaperones Monitor Movement Multimedia Naphthalene Naphthalenes Nasal Epithelium Nasal Lavage Fluid Natural regeneration Nuclear Receptors Organic solvent product Outcome Oxidation-Reduction Oxidative Stress Oxides Parents Particulate Pathway interactions Pattern Perchlorates Photobleaching Placenta Play Poison Population Predisposition Prevention intervention Primary Cell Cultures Process Production Protein Disulfide Isomerase Proteins Proteome Proteomics Rate Reaction Recording of previous events Regulation Relative (related person)Renal Tissue Report (account)Reproductive Health Reproductive Process Research Research Infrastructure Research Personnel Research Project Grants Research Support Research Training Respiratory System Rice Risk Rodent Role Route Sampling Scheme Scientist Screening procedure Sentinel Series Services Signal Pathway Signal Transduction Sister Site Small Interfering RNA Soil Soot Standardization Statistical Methods Structure of mucous membrane of nose Sulfhydryl Compounds Surface System Systems Analysis Techniques Technology Technology Transfer Terbium Testing Thyroid Function Tests Time Tissues Toxic Environmental Substances Toxic effect Toxicant exposure Toxicology Toxin Training Translations Transport Process Uncertainty United States Environmental Protection Agency Urine Validation Water Woman Work abstracting adduct analytical method assay development base body system concept contaminant transport cost cytotoxic density design exposed human population follow-up gonad function ground water hazard improved in vitro Assay in vitro Bioassay in vivo indium tin oxide inhibin innovation interest keratinocyte metabolomics methyl tert-butyl ether microbial miniaturize nanoparticle nanoscale new technology nonhuman primate novel parental monitoring particle particle exposure peroxiredoxin programs protein folding rapid detection receptor remediation reproductive research study response sensor single molecule statistics superfund chemical superfund site tool toxicant transcriptomics trophoblast wasting

项目摘要

Program Project Abstract. Biomarkers of Exposure to Hazardous Substances Although our ability to analyze hazardous material in waste sites has improved dramatically in recent years, we are very limited in our ability to trace the movement of hazardous materials from Superfund sites through various media or to prioritize and mitigate the hazards involved. Our ability to predict exposure or effect of these materials on humans and their environment is still more limited. This Program consists of 8 integrated projects, 3 research support cores, a training core, a research translation core and an administrative core to address these problems. We will determine the "ate and transport of hazardous materials in ground water, surface water, and air as they move from toxic waste sites using classical and innovative methodologies. We will examine the effect of some of these materials using an pidemiological approach. Concurrently we will develop sensitive systems for evaluating the exposure and effect of populations to these materials. Immunochemical, cell based and other systems will be used to detect biomarkers. Development of these biomarkers will be based on a fundamental understanding of the toxicological processes involved. The project will emphasize multiple organsystems with an in vivo emphasis on pulmonary and reproductive effects. We also will explore new technologies for thermal and bioremediation of toxic waste and address possible lealth risks associated with these technologies. Rapid immunochemical and cell based analysis will supplement classical technologies for the evaluation of sites, validating models of transport from these sites, as well as determining luman susceptibility, exposure and effect. Modern mass spectral technology will be evaluated for monitoring parent lazardous chemicals as well as biomarkers of exposure and effect. We are expanding the use of transcriptomics, aroteomics, metabolomics and integrated bio informatics technologies to discover new mechanisms of action of lazardous materials and biomarkers for their action. The biomarkers developed in this project will serve as biological dosimeters in epidemiological and ecological studies in this and sister projects. The technologies developed in the project will be tested at field sites and transferred to end users through a research translation core.

计划项目摘要。接触有害物质的生物标志物尽管近年来我们分析废物场有害物质的能力有了显着提高，但我们我们通过各种媒体追踪超级基金地点危险物质流动的能力非常有限或优先考虑并减轻所涉及的危险。我们预测这些材料对人类的暴露或影响的能力他们的环境仍然更加有限。该计划由8个综合项目、3个研究支持核心、一个培训核心、研究翻译核心和行政核心来解决这些问题。我们将确定 “当有害物质从有毒废物场转移时，它们在地下水、地表水和空气中被食用和运输使用经典和创新的方法。我们将使用以下方法检查其中一些材料的效果流行病学方法。同时，我们将开发敏感系统来评估暴露和影响人口对这些材料。免疫化学、基于细胞的系统和其他系统将用于检测生物标志物。这些生物标志物的开发将基于对毒理学过程的基本了解涉及。该项目将强调多个器官系统，其中重点关注肺和生殖系统影响。我们还将探索有毒废物热修复和生物修复的新技术，并解决可能的问题与这些技术相关的健康风险。快速免疫化学和基于细胞的分析将补充用于评估地点、验证这些地点的运输模型以及确定流明敏感性、暴露度和效果。现代质谱技术将用于监测母体进行评估危险化学品以及暴露和影响的生物标志物。我们正在扩大转录组学的使用，蛋白质组学、代谢组学和综合生物信息学技术，以发现新的作用机制其行为的危险材料和生物标志物。该项目开发的生物标志物将作为生物标志物该项目和姐妹项目中流行病学和生态研究中的剂量计。开发的技术项目将在实地进行测试，并通过研究翻译核心转移给最终用户。