STRUCTURAL STUDIES ON DYNEIN-MICROTUBULE COMPLEX

动力蛋白微管复合物的结构研究

• 批准号: 7723573
• 负责人: Masahide Kikkawa
• 金额: $ 1.26万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723573
• 关键词: ATP Hydrolysis; Axonal Transport; Chemicals; Chromosome Segregation; Complex; Computer Retrieval of Information on Scientific Projects Database; Dynein ATPase; Funding; Grant; Institution; Mechanics; Microtubules; Motor; Movement; Proteins; Research; Research Personnel; Resources; Source; United States National Institutes of Health; base; cell motility; disease-causing mutation; nanoscale

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Microtubule-based motors, dyneins, are nano-meter scale protein machineries and convert chemical energy derived from ATP hydrolysis to mechanical movement. The mechanical movement is employed for various essential intracellular motilities, such as axonal transport, chromosome segregation, and flagellar motility. The importance of dynein functions is underlined by several dynein-related diseases caused by mutation in dynein or dynein-associated proteins. However, little is known about how the mutations cause diseases. Even a basic question of how dyneins convert chemical energy to mechanical movement is not well understood.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 基于微管的马达（动力蛋白）是纳米级蛋白质机器，可将 ATP 水解产生的化学能转化为机械运动。机械运动用于各种重要的细胞内运动，例如轴突运输、染色体分离和鞭毛运动。由动力蛋白或动力蛋白相关蛋白突变引起的几种动力蛋白相关疾病强调了动力蛋白功能的重要性。然而，人们对突变如何导致疾病知之甚少。甚至动力蛋白如何将化学能转化为机械运动的基本问题也没有得到很好的理解。