Behavior-Modifying Compounds for Disease Vector Control

用于病媒控制的行为改变化合物

基本信息

批准号：
7234109
负责人：
John Paul Grieco
金额：
$ 60.33万
依托单位：
HENRY M. JACKSON FDN FOR THE ADV MIL/MED
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-08 至 2009-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7234109
关键词：
Abate Address Adult Aedes Affect Agreement Agriculture Anopheles Genus Area Arthropod Vectors Arthropods Bartonella Infections Behavior Behavioral Belize Biological Assay Biometry Bite Boxing Brazil Cessation of life Chemical Actions Chemicals Chemistry Chlorinated Hydrocarbons Clothing Collection Communicable Diseases Condition Country Culicidae Data Deet Dengue Development Disease Disease Vectors Effectiveness End Point Entomology Environment Evaluation Exhibits Faculty Feeding Methods Funding Goals Government Government Officials Health Sciences Hour Housing Human In Vitro Industry Insect Bites Insecta Insecticides Irritants Laboratories Lead Leishmaniasis Libraries Lutzomyia genus Malaria Marketing Maryland Measures Membrane Metabolic Methods Modeling Monitor Movement North Carolina Numbers Organism Orphan Participant Permethrin Peru Phase Phlebotomus Poison Population Prevention Preventive Medicine Principal Investigator Property Public Health Publishing Purpose Research Research Personnel Risk Sand Flies Screening procedure Services Simulate Site Skin Solutions Specific qualifier value Standards of Weights and Measures Stereoisomer Structural Models System Technology Test Result Testing Thailand TimeLine Today Toxic effect United States Department of Agriculture United States National Institutes of Health Universities Work Writing alphacypermethrin analog analytical method base behavior influence behavior test chemical function chemical synthesis combinatorial chemistry commercialization comparative cooking cyhalothrin decamethrin dichlorodiphenyltrichloroethane disease transmission disorder control experience human subject interest killings man molecular modeling novel novel strategies prevent programs pyrethroid response statistics success tool toxicant vector vector control

项目摘要

DESCRIPTION (provided by applicant): A major insecticide company (BASF) is working with a network of investigators to develop chemicals that influence behaviors of arthropod vectors of infectious diseases. The goals are to identify chemicals that alter arthropod behaviors and to evaluate their efficacy in reducing risks of disease transmission by preventing man-vector contact. Compounds identified in this program will be transferred to BASF for commercial development. The need for new disease control tools is urgent and greatest in poor countries; so the chemical must be easily and cheaply manufactured. Thus, known synthetic compounds will be the primary focus of proposed research. For public health, the ideal chemical is one that persists in or on treated substrates but rapidly degrades in living systems. Emphasis will be on exploratory testing to compare various test methods against different vector species, and to use optimized tests as a high throughput method to compare different chemicals for levels of repellent, irritant and toxicant actions against disease vectors. The First Specific Aim is to optimize a suite of standardized tests. Testing will consist of (1) an in vitro test for topical repellent action (prevent biting), (2) a single exposure and escape test system for contact irritant actions, (3) a set of three chambers (a central exposure chamber bracketed by treated and untreated chambers) as a specific test for repellent actions, and (4) a test for contact toxicity. Tests will be conducted with recently colonized vectors of malaria, dengue, leishmaniasis and bartonellosis. The Second Specific Aim is to use specific repellent, irritant or toxic chemicals as lead compounds for developing, through combinatorial chemistry technology, other experimental chemicals. The Third Specific Aim is to field test selected compounds that demonstrate potent behavior-modifying activity. Field testing will consist of monitoring the movement of disease vectors into and out of experimental huts, as well as observations on biting and 24-hour survival, and will consist of comparisons between treated and untreated (control) huts. A stochastic model and standard statistics will be used to evaluate data from experimental huts. We propose that success with our research plan will achieve both a novel agent(s) and a novel strategy(s) for disease control. Test data will be given to BASF as a basis for deciding whether to proceed with further toxicological evaluations and commercial development of promising compounds.

描述（由申请人提供）：一家大型杀虫剂公司（巴斯夫）正在与研究人员网络合作开发影响传染病节肢动物媒介行为的化学品。目标是识别改变节肢动物行为的化学物质，并评估它们通过防止人与媒介接触来降低疾病传播风险的功效。该计划中确定的化合物将转移给巴斯夫进行商业开发。贫穷国家对新疾病控制工具的需求最为迫切和最大；因此，这种化学品的制造必须容易且成本低廉。因此，已知的合成化合物将是拟议研究的主要焦点。对于公共健康而言，理想的化学品是一种能够持久存在于处理过的基质中或表面但在生命系统中迅速降解的化学品。重点将放在探索性测试上，以比较针对不同媒介物种的各种测试方法，并使用优化测试作为高通量方法来比较不同化学品对疾病媒介的驱避、刺激和毒害作用水平。第一个具体目标是优化一套标准化测试。测试将包括 (1) 局部驱避作用（防止咬伤）的体外测试，(2) 用于接触刺激作用的单次暴露和逃逸测试系统，(3) 一组三个室（中央暴露室由经处理和未经处理的室）作为驱避作用的具体测试，以及（4）接触毒性测试。将对最近定植的疟疾、登革热、利什曼病和巴尔通体病载体进行测试。第二个具体目标是使用特定的驱虫剂、刺激性或有毒化学品作为先导化合物，通过组合化学技术开发其他实验化学品。第三个具体目标是对选定的化合物进行现场测试，以证明其具有有效的行为改变活性。现场测试将包括监测疾病媒介进出实验小屋的情况，以及对叮咬和 24 小时存活率的观察，并将包括经过处理和未经处理（对照）小屋之间的比较。将使用随机模型和标准统计数据来评估实验小屋的数据。我们建议，我们的研究计划的成功将实现疾病控制的新药物和新策略。测试数据将提供给巴斯夫，作为决定是否继续进行进一步毒理学评估和有前景化合物的商业开发的基础。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Biting patterns of Anopheles minimus complex (Diptera: Culicidae) in experimental huts treated with DDT and deltamethrin.

用 DDT 和溴氰菊酯处理的实验小屋中微小按蚊复合体（双翅目：蚊科）的叮咬模式。

DOI：
发表时间：
2008-12
期刊：
影响因子：
0
作者：
Polsomboon, Suppaluck;Poolprasert, Pisit;Suwonkerd, Wannapa;Bangs, Michael J;Tanasinchayakul, Somchai;Akratanakul, Pongthep;Chareonviriyaphap, Theeraphap
通讯作者：
Chareonviriyaphap, Theeraphap

Irritant and repellent behavioral responses of Aedes aegypti male populations developed for RIDL disease control strategies.

为 RIDL 疾病控制策略而开发的埃及伊蚊雄性种群的刺激和排斥行为反应。

DOI：
发表时间：
2010-11
期刊：
影响因子：
2.1
作者：
Kongmee, Montathip;Nimmo, Derric;Labbé, Geneviève;Beech, Camilla;Grieco, John;Alphey, Luke;Achees, Nicole
通讯作者：
Achees, Nicole

A novel high-throughput screening system to evaluate the behavioral response of adult mosquitoes to chemicals.

一种新型高通量筛选系统，用于评估成年蚊子对化学品的行为反应。

DOI：
发表时间：
2005-12
期刊：
影响因子：
0
作者：
Grieco, John P;Achee, Nicole L;Sardelis, Michael R;Chauhan, Kamlesh R;Roberts, Donald R
通讯作者：
Roberts, Donald R

A new classification system for the actions of IRS chemicals traditionally used for malaria control.

针对传统上用于疟疾控制的国税局化学品作用的新分类系统。

DOI：
发表时间：
2007
期刊：
影响因子：
3.7
作者：
Grieco, John P;Achee, Nicole L;Chareonviriyaphap, Theeraphap;Suwonkerd, Wannapa;Chauhan, Kamal;Sardelis, Michael R;Roberts, Donald R
通讯作者：
Roberts, Donald R

The use of an experimental hut for evaluating the entering and exiting behavior of Aedes aegypti (Diptera: Culicidae), a primary vector of dengue in Thailand.

使用实验小屋评估埃及伊蚊（双翅目：库蚊科）的进出行为，埃及伊蚊是泰国登革热的主要媒介。

DOI：
发表时间：
2005-12
期刊：
影响因子：
0
作者：
Chareonviriyaphap, Theeraphap;Suwonkerd, Wannapa;Mongkalangoon, Piti;Achee, Nicole;Grieco, John;Farlow, Bob;Roberts, Donald
通讯作者：
Roberts, Donald