BIOMECHANICS OF LOOPING IN EMBRYONIC HEART

胚胎心脏循环的生物力学

• 批准号: 7722325
• 负责人: LARRY A TABER
• 金额: $ 0.32万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722325
• 关键词: Biomechanics; Cardiac; Computer Retrieval of Information on Scientific Projects Database; Computer Simulation; Development; Embryonic Heart; Funding; Gene Expression; Goals; Grant; Growth; Institution; Link; Morphogenesis; Research; Research Personnel; Resources; Source; Stress; United States National Institutes of Health; viscoelasticity

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term goals of our research are to determine the biomechanical factors involved in cardiac morphogenesis and to develop a computational model for the embryonic heart that can be used to predict developmental abnormalities. Determining the biomechanical factors involved in looping would provide information that will be needed by researchers seeking to establish the link between gene expression and looping mechanisms. We would like to see the capability to handle stress-dependent growth and remodeling, as well as nonlinear viscoelasticity.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们研究的长期目标是确定参与心脏形态发生的生物力学因素，并开发可用于预测发育异常的胚胎心脏计算模型。 确定循环中涉及的生物力学因素将为寻求建立基因表达和循环机制之间联系的研究人员提供所需的信息。 我们希望看到处理应力依赖性生长和重塑以及非线性粘弹性的能力。