TG DAC: MONTE CARLO CALCULATION OF SYSTEM MATRIX FOR PET INSERT DEVICE FOR BREA

TG DAC：BREA 宠物插入装置系统矩阵的蒙特卡罗计算

• 批准号: 7723321
• 负责人: YUAN-CHUAN TAI
• 金额: $ 0.05万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723321
• 关键词: Breast; Computer Retrieval of Information on Scientific Projects Database; Computer software; Development; Devices; Funding; Gamma Rays; Goals; Grant; Image; Institution; Modeling; Patients; Performance; Positron-Emission Tomography; Probability; Radioactivity; Research; Research Personnel; Resolution; Resources; Source; System; United States National Institutes of Health; base; computing resources; detector; image reconstruction; programs; reconstruction; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are developing a new type of PET (positron emission tomography) device for breast imaging applications that uses a high-resolution semi-circular ring of detectors within a conventional PET/CT scanner to zoom-in on the region around a breast to obtain high-resolution images. To aid the development of our system, we must perform realistic Monte Carlo simulations to understand the performance of our system and to generate a system matrix. A system matrix represents the probability of detecting a pair of gamma rays originated from a voxel in the imaging field of view. One can use the system matrix in a statistical iterative reconstruction framework to estimate the distribution of radioactivity in the patient. We have evaluated existing Monte Carlo simulation packages such as GATE, a Geant4-based simulation program, to perform this simulation study, but found that none of the existing software will handle our unique system geometry efficiently. We are developing our own simulation program that specifically models our geometry in an efficient fashion. We would like to evaluate the accuracy of our simulation program, and once done, generate the full system matrix, and perform image reconstruction using the Teragrid computing resources. To achieve these goals, we anticipate that we will need a full 30,000 SU development allocation.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们正在开发一种用于乳腺成像应用的新型 PET（正电子发射断层扫描）设备，该设备使用传统 PET/CT 扫描仪内的高分辨率半圆环探测器来放大乳房周围区域，以获得高分辨率图像。 - 分辨率图像。为了帮助我们系统的开发，我们必须执行真实的蒙特卡罗模拟，以了解系统的性能并生成系统矩阵。系统矩阵表示检测到源自成像视场中的体素的一对伽马射线的概率。人们可以在统计迭代重建框架中使用系统矩阵来估计患者体内放射性的分布。我们评估了现有的蒙特卡罗模拟软件包（例如基于 Geant4 的模拟程序 GATE）来执行这项模拟研究，但发现现有软件都无法有效地处理我们独特的系统几何形状。我们正在开发自己的模拟程序，专门以有效的方式对我们的几何形状进行建模。我们想要评估我们的模拟程序的准确性，完成后生成完整的系统矩阵，并使用 Teragrid 计算资源执行图像重建。为了实现这些目标，我们预计需要 30,000 个 SU 开发拨款。