TG DAC: MONTE CARLO CALCULATION OF SYSTEM MATRIX FOR PET INSERT DEVICE FOR BREA

TG DAC：BREA 宠物插入装置系统矩阵的蒙特卡罗计算

• 批准号: 7723321
• 负责人: YUAN-CHUAN TAI
• 金额: $ 0.05万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723321
• 关键词: Breast; Computer Retrieval of Information on Scientific Projects Database; Computer software; Development; Devices; Funding; Gamma Rays; Goals; Grant; Image; Institution; Modeling; Patients; Performance; Positron-Emission Tomography; Probability; Radioactivity; Research; Research Personnel; Resolution; Resources; Source; System; United States National Institutes of Health; base; computing resources; detector; image reconstruction; programs; reconstruction; simulation; Breast; Computer Retrieval of Information on Scientific Projects Database; Computer software; Development; Devices; Funding; Gamma Rays; Goals; Grant; Image; Institution; Modeling; Patients; Performance; Positron-Emission Tomography; Probability; Radioactivity; Research; Research Personnel; Resolution; Resources; Source; System; United States National Institutes of Health; base; computing resources; detector; image reconstruction; programs; reconstruction; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are developing a new type of PET (positron emission tomography) device for breast imaging applications that uses a high-resolution semi-circular ring of detectors within a conventional PET/CT scanner to zoom-in on the region around a breast to obtain high-resolution images. To aid the development of our system, we must perform realistic Monte Carlo simulations to understand the performance of our system and to generate a system matrix. A system matrix represents the probability of detecting a pair of gamma rays originated from a voxel in the imaging field of view. One can use the system matrix in a statistical iterative reconstruction framework to estimate the distribution of radioactivity in the patient. We have evaluated existing Monte Carlo simulation packages such as GATE, a Geant4-based simulation program, to perform this simulation study, but found that none of the existing software will handle our unique system geometry efficiently. We are developing our own simulation program that specifically models our geometry in an efficient fashion. We would like to evaluate the accuracy of our simulation program, and once done, generate the full system matrix, and perform image reconstruction using the Teragrid computing resources. To achieve these goals, we anticipate that we will need a full 30,000 SU development allocation.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们正在开发一种新型的PET（正电子发射断层扫描）设备，用于乳房成像应用，该设备在常规PET/CT扫描仪内使用高分辨率的半圆形探测器，以放大乳房周围的区域，以获得高分辨率图像。为了帮助我们的系统开发，我们必须执行现实的蒙特卡洛模拟，以了解系统的性能并生成系统矩阵。系统矩阵表示检测一对伽马射线的概率，源自视野中的体素。可以在统计迭代重建框架中使用系统矩阵来估计患者的放射性分布。我们已经评估了现有的蒙特卡洛模拟软件包，例如基于Geant4的仿真程序Gate，以执行该模拟研究，但发现没有一个现有软件将有效地处理我们的独特系统几何形状。我们正在开发自己的仿真程序，该程序以有效的方式专门建模我们的几何形状。我们想评估我们的仿真程序的准确性，并完成后，生成完整的系统矩阵，并使用TeraGRID计算资源执行图像重建。为了实现这些目标，我们预计我们将需要30,000个SU开发分配。