THE GENETIC DETERMINANTS OF BIPOLAR DISORDER AND SCHIZOPHRENIA

双相情感障碍和精神分裂症的遗传决定因素

• 批准号: 7723396
• 负责人: TIFFANY A GREENWOOD
• 金额: $ 0.05万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723396
• 关键词: Bipolar Disorder; Candidate Disease Gene; Clinical; Cloning; Complex; Computer Retrieval of Information on Scientific Projects Database; Custom; Data; Disease; Dissection; Funding; Gene Chips; Genes; Genetic; Genetic Determinism; Genetic Heterogeneity; Genome; Genomics; Genotype; Grant; Information Networks; Institution; Methods; National Institute of Mental Health; Nature; Numbers; Phenotype; Research; Research Personnel; Resources; Scanning; Schizophrenia; Signal Transduction; Source; Susceptibility Gene; United States National Institutes of Health; endophenotype; gene discovery; gene interaction; genetic association; genome wide association study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The discovery of genes predisposing to complex diseases, such as bipolar disorder and schizophrenia, has proven to be very difficult. Over the years, genome linkage scans have identified a number of regions that may harbor candidate genes, yet none of these linkage findings has led to cloning of causative genes for either disorder. This may be due to the modest nature of the linkage signals and the broad genetic regions they encompass, a likely result of the well-known clinical and genetic heterogeneity associated with bipolar disorder, schizophrenia, and psychiatric illness in general. Researchers have now turned to alternative strategies, such as the use of endophenotypes, candidate gene studies, and large-scale genomic association studies, in the hope that these methods may aid in the genetic dissection of complex disorders. We have undertaken several such projects to discover the underlying determinants of bipolar disorder and schizophrenia. In particular, as part of the Consortium on the Genetics of Schizophrenia (COGS) we have collected 12 endophenotypes for schizophrenia and are pursuing linkage studies, as well as a large scale candidate gene study through the use of a custom gene chip that has just complete genotyping. We will also pursue gene-gene interaction studies guided by the results of our genetic network analyses. Additionally, as part of the NIMH Genetics Initiative for Bipolar Disorder, which is participating in the genotyping initiative sponsored by the Genetic Association Information Network (GAIN), we will pursue whole genome association studies of bipolar disorder and related phenotypes. We anticipate that we will receive the genetic data for this project in October. As these are rather large-scale efforts, the computing requirements will be substantial, exceeding our current capabilities as far as efficiency is concerned.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 事实证明，发现复杂疾病的基因（例如躁郁症和精神分裂症）非常困难。多年来，基因组链接扫描已经确定了许多可能具有候选基因的区域，但是这些连锁发现都没有导致任何一种疾病的因果基因克隆。这可能是由于连锁信号的适度性质及其所包含的广泛遗传区域，这可能是众所周知的临床和遗传异质性与躁郁症，精神分裂症和精神疾病相关的众所周知的结果。现在，研究人员已转向替代策略，例如使用内表型，候选基因研究和大规模基因组关联研究，希望这些方法可以帮助复杂疾病的遗传解剖。我们已经进行了几个这样的项目，以发现躁郁症和精神分裂症的潜在决定因素。特别是，作为精神分裂症遗传学（COGS）遗传学联盟的一部分，我们收集了12种用于精神分裂症的内表型，正在进行连锁研究，以及通过使用刚刚完成的自定义基因芯片的大规模候选基因研究基因分型。我们还将根据我们的遗传网络分析结果进行基因 - 基因相互作用研究。此外，作为NIMH遗传学对双相情感障碍的一部分，该计划参与了由遗传关联信息网络（GANE）赞助的基因分型倡议，我们将探讨对双相情感障碍和相关表概况的整个基因组关联研究。我们预计我们将在10月收到该项目的遗传数据。由于这些是相当大的努力，就效率而言，计算要求将是很大的，超出了我们当前的功能。