AIP1 AND P9 PEPTIDE: HIV

AIP1 和 P9 肽：HIV

• 批准号: 7726208
• 负责人: CHRISTOPHER P. HILL
• 金额: $ 0.31万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-18 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7726208
• 关键词: Binding; Cells; Computer Retrieval of Information on Scientific Projects Database; Decompression Sickness; Equine Infectious Anemia Virus; Event; Funding; Grant; HIV; HIV Budding; Institution; Lipids; Membrane; Pathway interactions; Peptides; Play; Proteins; Research; Research Personnel; Resources; Retroviridae; Role; Source; United States National Institutes of Health; Vesicle; Virus; insight; late endosome

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our research focuses on studying how HIV buds from cells by utilizing cellular machinery normally used in the formation of luminal vesicles of late endosomes. Several proteins in this pathway are required for the budding of several retroviruses, including HIV. One protein in this pathway is AIP1, which binds directly to both HIV and EIAV through a PPXY late domain found in the virus. It is also believed that AIP1 plays an important role in membrane bending events since AIP1 binds to specific lipids found in the late endosome, in addition to binding to proteins which are also believed to function in membrane bending. Structural information on AIP1 and its binding partners will provide insight into how AIP1 binds viruses and how AIP1 could function in bending membranes, both of which are critical for viruses to properly bud from the cell.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们的研究重点是研究通常用于形成晚期内体腔囊泡的细胞机械来研究细胞中的艾滋病毒芽。 该途径中的几种蛋白质是需要逆转录病毒（包括HIV）的几种蛋白质。 该途径中的一种蛋白质是AIP1，它通过病毒中发现的PPXY晚期结构域直接与HIV和EIAV结合。 还认为AIP1在膜弯曲事件中起着重要作用，因为AIP1与晚期内体中发现的特定脂质结合，此外还与蛋白质结合，而蛋白质也被认为在膜弯曲中起作用。 有关AIP1及其结合伙伴的结构信息将提供有关AIP1如何结合病毒以及AIP1在弯曲膜中的功能的洞察力，这两种信息对于病毒适当地从细胞中芽起来至关重要。