DISCOVERY OF PHARMACOLOGIC PROBES AND THERAPEUTICS

药理学探针和治疗方法的发现

• 批准号: 7721536
• 负责人: RICHARD W FITCH
• 金额: $ 0.1万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721536
• 关键词: Adverse effects; Biological Factors; Chemistry; Computer Retrieval of Information on Scientific Projects Database; Disease; Funding; Grant; Institution; Laboratories; Lead; Pharmaceutical Chemistry; Pharmaceutical Preparations; Pharmacology; Purpose; Research; Research Personnel; Resources; Source; Therapeutic; United States National Institutes of Health; Work; human disease; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This work relates to the chemistry and pharmacology of natural products. Research in this laboratory is multifaceted, including isolation and structural characterization of novel biologically active compounds, as well as their synthesis and determination of their pharmacology. The purpose of this research is to discover compounds useful as pharmacologic probes and potential therapeutics for human disease. Medicinal chemistry is also used to this end, in that the compounds isolated from the natural source are lead compounds which can be chemically modified to tune their pharmacology, with the aim of developing selective drugs for treatment of disease with increased potency and efficacy, while reducing potential side effects.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项工作涉及天然产物的化学和药理学。该实验室的研究是多方面的，包括新型生物活性化合物的分离和结构表征，以及它们的合成和药理学测定。这项研究的目的是发现可用作药理学探针和人类疾病的潜在疗法的化合物。药物化学也用于此目的，因为从天然来源中分离出的化合物是先导化合物，可以对其进行化学修饰以调整其药理学，目的是开发选择性药物来治疗疾病，提高效力和功效，同时减少潜在的副作用。