Gold-Catalysed Cycloisomerisations

金催化环异构化

• 批准号: EP/F031254/1
• 负责人: Paul Davies
• 金额: $ 20.33万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FF031254%2F1
• 关键词: Gold; Catalysed; Cycloisomerisations

Cyclic structures are are ubiquitous in pharmaceuticals, agrochemicals, natural products and fine chemicals. Thus the preparation of ring systems and being able to control cyclisation reactions is very important and presents a major challenge to organic synthesis. New methods to access these type of species more readily are therefore highly desirable. Shorter, more flexible, easy and efficient routes into useful molecules can have several significant benefits to the wider community. This includes the use of fewer reagents, less hazardous chemicals, and less energy to make important molecules. All of these factors have subsequent benefits in terms of using less of our limited natural resources (chemical and energy) and producing less of the dangerous waste materials that must be disposed off. Potentially, more efficient strategies and transformations can also have economic benefits, making overall processes and the resulting products less costly. The importance of developing more effective approaches cannot therefore be understated and in this research we look at using new highly efficient catalytic methods to access a wide variety of carbo and heterocyclic structures that have clear application throughout synthetic chemistry.

环状结构在药物、农用化学品、天然产物和精细化学品中普遍存在。因此，环系统的制备和能够控制环化反应非常重要，并且对有机合成提出了重大挑战。因此，非常需要更容易地获取这些类型物种的新方法。更短、更灵活、更简单和更有效的合成有用分子的途径可以为更广泛的社区带来一些显着的好处。这包括使用更少的试剂、更少的危险化学品和更少的能量来制造重要的分子。所有这些因素都会带来后续好处，即减少使用有限的自然资源（化学品和能源）并减少产生必须处理的危险废料。更有效的策略和转型也可能带来经济效益，从而降低整个流程和最终产品的成本。因此，开发更有效方法的重要性不容低估，在这项研究中，我们着眼于使用新的高效催化方法来获得各种碳和杂环结构，这些结构在整个合成化学中都有明确的应用。

项目成果

Gold-catalysed room-temperature cycloisomerisation of alkynes and unactivated enolisable ketones.

金催化的炔烃和未活化烯醇化酮的室温环异构化。

• DOI: http://dx.10.1039/c003473h
• 发表时间: 2010
• 期刊: Organic & biomolecular chemistry
• 影响因子: 3.2
• 作者: Davies PW

Gold-Catalysed Cycloisomerisation of Ynamides To Access 2,2-Disubstituted Tetrahydrothiophene Motifs

金催化的酰胺环异构化获得 2,2-二取代四氢噻吩基序

• DOI: 10.1055/a-1434-4273
• 发表时间: 2021-03-13
• 期刊: Synlett
• 影响因子: 2
• 作者: P. Davies;P. Kaur
• 通讯作者: P. Kaur