Patient-oriented research in early life origins of CVD

以患者为中心的 CVD 生命早期起源研究

基本信息

批准号：
7247880
负责人：
MATTHEW W GILLMAN
金额：
$ 17.81万
依托单位：
HARVARD PILGRIM HEALTH CARE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-30 至 2011-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7247880
关键词：
14 year old 3 year old 4 year old Academy Address Adolescence Adolescent Adult Advisory Committees Age Age-Months Age-Years Alcohol consumption Aliquot Allergic rhinitis American American Heart Association Americas Ancillary Study Anemia Animal Model Animals Annual Reports Anthropometry Antioxidants Appendix Appointment Area Asians Asthma Atopic Dermatitis Attention Award Barker Hypothesis Basic Science Behavioral Behavioral Mechanisms Belarus Binding Biogenesis Biological Biological Assay Biometry Biosocial Birth Birth Weight Blood Blood Pressure Blood specimen Board Certification Body Size Body mass index Book Chapters Boston Brain Breast Feeding Calcium Canada Cardiovascular Diseases Cardiovascular system Caring Categories Cause of Death Centers for Disease Control and Prevention (U.S.)Child Child Care Child Development Childhood Childhood Asthma Chronic Chronic Disease Clinic Clinical Clinical Investigator Clinical Research Clinical Trials Clinical effectiveness Cognition Cognitive Cohort Studies Collaborations Colorado Communication Communities Complement Computerized Medical Record Computerized Medical Records Systems Conceptions Condition Congresses Consultations Consumption Contracts Corticotropin-Releasing Hormone Counseling DNA Data Data Analyses Data Collection Data Set Data Sources Databases Daughter Deposition Depth Dermatology Development Diabetes Mellitus Diagnosis Diet Discipline Disease Doctor of Philosophy Doctor of Public Health Drug usage Eating Disorders Economics Edetic Acid Education Educational Curriculum Educational process of instructing Educational workshop Elderly Elements Endocrine Ensure Environment Epidemic Epidemiologic Studies Epidemiologist Epidemiology Equilibrium Erythrocytes Ethical Issues Etiology Europe European Union Evaluation Exclusive Breastfeeding Extrinsic asthma Faculty Family Family Study Family history of Fatty Acids Fatty acid glycerol esters Feedback Fellowship Fellowship Program Fetal Growth Figs - dietary Fishes Flowers Follow-Up Studies Fostering Foundations Frequencies Fund Raising Funding Funding Agency Future Gastroenterology Gender General Hospitals Generations Genes Genetic screening method Genome Germany Gestational Age Gestational Diabetes Glucocorticoids Goals Grant Grooming Group Practice Growth Hand Health Health Insurance Health Maintenance Organizations Health Policy Health Services Health Services Research Healthcare Hearing Height Heparin Hormonal Hormonal Risk Factor Hormones Hospital Records Hospitals Hour Human Resources Hypersensitivity Hypertension Hypotension Illicit Drugs Immigrant Immune Immunity Immunologic Markers Individual Infant Infant Health Inflammation Inpatients Institutes Insulin Resistance Intake Internal Medicine International Internist Intervention Intervention Studies Intervention Trial Iodine Journals Knowledge Laboratories Lead Leadership Learning Length Letters Leukocytes Life Life Cycle Stages Life Style Link Lipoproteins Literature Longitudinal Studies Lymphocyte Mails Manuscripts Master&apos s Degree Measurement Measures Medical Medical Education Medical Faculty Medical Research Medical Students Medical Surveillance Medicine Menopause Mentors Mentorship Mercury Metabolic Metabolic Diseases Metabolic syndrome Mid-Career Clinical Scientist Award (K24)Minnesota Minority Modeling Mothers Myocardial Ischemia NCI Scholars Program Names National Health Service Corps National Institute of Child Health and Human Development National Institute of Mental Health National Research Service Awards Neonatology New York Non-Insulin-Dependent Diabetes Mellitus North Carolina Nuclear Numbers Nursing Faculty Nutrient Obesity Observational Study Occupations Omega-3 Fatty Acids Oocytes Operative Surgical Procedures Oral Examination Outcome Outpatients Overweight Paper Participant Pathway interactions Patient Self-Report Patient currently pregnant Patients Pediatric Hospitals Pediatric Research Pediatrics Peer Review Peer Review Grants Perinatal Periodontal Diseases Periodontitis Personal Satisfaction Persons Pharmaceutical Preparations Phase Physical activity Physicians Placement Placental Hormones Plasma Policies Population Population Sciences Positioning Attribute Postdoctoral Fellow Postpartum Depression Postpartum Period Pre-Eclampsia Pregnancy Pregnancy Outcome Pregnancy Trimesters Pregnant Women Premature Birth Preparation Preschool Child Prevention Prevention Research Preventive Intervention Primary Health Care Principal Investigator Private Practice Procedures Process Productivity Program Development Program Effectiveness Progress Reports Property Proteins Psychotic Disorders Public Health Public Health Schools Publications Published Comment Publishing Race Randomized Controlled Clinical Trials Randomized Controlled Trials Range Rate Reading Records Recruitment Activity Reporting Reproductive Health Reproductive History Research Research Design Research Ethics Research Infrastructure Research Personnel Research Project Grants Research Training Residencies Resources Respondent Review Literature Rewards Risk Risk Factors Role Safety Sample Size Sampling Schedule Schools Science Scientist Score Scotland Screening for cancer Screening procedure Secure Services Sexuality Shapes Site Skinfold Thickness Smoke Societal Factors Societies Son Source Specific qualifier value Staging Standards of Weights and Measures Steroids Stream Stress Stroke Structure Students Sum Supervision System Taste Perception Taurine Techniques Testing Thailand Thinking Thyroid Gland Time Time Management Today Touch sensation Training Training Programs Trans Fatty Acids Translations Travel Triceps Brachii Muscle Tube Umbilical Cord Blood Umbilical cord structure United States United States Health Resources and Services Administration Universities Visit Wages Week Weight Weight Gain Woman Wood material Work Writing abstracting adiponectin atopy base behavior change boys cardiovascular risk factor career case-based chronic care model clinical epidemiology cohort cost effectiveness critical developmental period cytokine data management day design disability early childhood editorial energy balance experience falls feeding fetal follow-up forest girls human study hypertension prevention immunoregulation impression improved infancy innovation instructor interdisciplinary approach interest intergenerational lecturer male malignant breast neoplasm medical schools member modifiable risk neuropsychiatry next generation nutrition nutritional epidemiology obesity prevention obesity risk patient home care patient oriented patient oriented research pediatrician peer pleasure postnatal prenatal pressure prevent professor programs prospective psychologic reproductive epidemiology research study response sex skills social success text searching transcription factor trend

项目摘要

DESCRIPTION (provided by applicant): Factors operating not only in adult life, but also from conception, have impact on lifelong cardiovascular health. Animal and human studies, including our own, are now providing intriguing clues into the pre- and perinatal determinants of childhood obesity and cardiovascular risk. But prospective data are lacking, and translation into preventive interventions has only just begun. With the support from this K24 competing continuation grant, Dr. Gillman and his mentees will focus intensively on this area of research for the next five years, a critical period not only for the field itself, but also for continuing to expand his potential for significant contributions and for nurturing the next generation of patient-oriented researchers in this field. The specific aims of this proposal are (1) To examine pre- and perinatal determinants of childhood obesity and cardiovascular risk factors. These analyses will take advantage of the infrastructure provided by the ongoing NIH-funded Project Viva, a prospective cohort study of pregnant women and their children. (2) To provide a nourishing professional environment for the training and advancement of beginning clinical researchers, who will conduct studies within Project Viva and other ongoing patient-oriented research projects in the area of the life course approach to chronic disease. Major foci will be in the areas of (1) pre- and perinatal origins of obesity, cardiovascular risk, asthma, and cognition; (2) determinants of diet and physical activity in adolescence; and (3) innovative interventions to prevent obesity in young children.

描述（由申请人提供）：影响终生心血管健康的因素不仅在成年生活中起作用，而且在受孕时也起作用。动物和人类研究，包括我们自己的研究，现在为了解儿童肥胖和心血管风险的产前和围产期决定因素提供了有趣的线索。但缺乏前瞻性数据，预防性干预措施的转化才刚刚开始。在 K24 竞争性继续资助的支持下，吉尔曼博士和他的学员将在未来五年集中精力研究这一领域，这不仅是该领域本身的关键时期，也是继续扩大其重大潜力的关键时期。贡献并培养该领域下一代以患者为中心的研究人员。该提案的具体目标是（1）检查儿童肥胖和心血管危险因素的产前和围产期决定因素。这些分析将利用正在进行的 NIH 资助的 Viva 项目提供的基础设施，该项目是一项针对孕妇及其子女的前瞻性队列研究。 (2) 为新晋临床研究人员的培训和晋升提供滋养的专业环境，他们将在 Viva 项目和其他正在进行的慢性病生命过程方法领域的以患者为中心的研究项目中进行研究。主要关注领域是 (1) 肥胖、心血管风险、哮喘和认知的产前和围产期起源； (2)青春期饮食和体力活动的决定因素； (3) 预防幼儿肥胖的创新干预措施。