Mentoring of Clinical Investigators in Patient Oriented Research

指导临床研究人员进行以患者为导向的研究

• 批准号: 7249107
• 负责人: Eric C. Strain
• 金额: $ 18.33万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7249107
• 关键词: Address; Agonist; Analgesics; Area; Award; Behavior Therapy; Biological Availability; Buprenorphine; Characteristics; Classification; Clinical; Clinical Investigator; Clinical Pharmacology; Clinical Research; Clinical Trials; Cocaine; Cocaine Abuse; Cocaine Dependence; Communities; Comorbidity; Development; Disease; Dose; Drug Addiction; Drug abuse; Environment; Faculty; Fellowship; Funding; Goals; Grant; Human; Intervention; Laboratory Study; Lead; Maintenance; Mentors; Mentorship; Mission; National Institute of Drug Abuse; New Agents; Opiate Addiction; Opioid; Oral; Patients; Personal Satisfaction; Persons; Pharmaceutical Preparations; Pharmacotherapy; Physical Dependence; Physicians; Pilot Projects; Positioning Attribute; Psychiatry; Purpose; Range; Recruitment Activity; Relative (related person); Reporting; Research; Research Personnel; Resources; Role; Safety; Schedule; Scientific Advances and Accomplishments; Series; Substance Use Disorder; Substance abuse problem; Support of Research; Symptoms; Testing; Training; Tramadol; United States; United States Food and Drug Administration; United States National Institutes of Health; Universities; Withdrawal; Woman; Work; addiction; base; career; experience; medical schools; member; men; mu opioid receptors; next generation; patient oriented research; prescription document; prescription procedure

DESCRIPTION (provided by applicant): This is an application for a K24 Mid-career Investigator Award in Patient Oriented Research (POR). The applicant is Eric Strain, a physician-researcher in the Department of Psychiatry at Johns Hopkins University School of Medicine. Dr. Strain has devoted his career to POR, and specifically to issues related to research on drug abuse and to treatment of substance abusing patients. His areas of focus have included the development of medications for the treatment of opioid and cocaine dependence, the testing of medications combined with behavioral treatment interventions, the role of psychiatric symptoms and comorbidity in substance use disorders, the testing of abuse liability of medications, and the special treatment needs of women and men with substance abuse. This application describes the candidate's three immediate career goals (to recruit young physicians/clinical investigators to conduct research fellowships in clinical addictions research, to integrate these clinical investigators into ongoing and new studies of POR conducted at the BPRU by providing direct experience in all aspects of clinical investigation, and to assist and mentor these clinical investigators in the transition from fellow to junior faculty member, encouraging each to continue in a career path of addictions-related research). In addition, three long-term career goals are also described (to develop a group of junior, mid-level, and senior clinician investigators with expertise in conducting addictions-related research to serve as a next generation of investigators in substance abuse research at Johns Hopkins, to maintain current investigative strengths of the BPRU while building new complementary areas of clinical research through collaborative efforts within the research community, and to utilize this investigative team in advancing scientific understanding of addictive disorders and their treatment through coordinated efforts). These goals will be accomplished through currently funded research efforts, and a clinical pharmacology study is succinctly presented to illustrate work currently funded by the candidate. In addition, funds from the present application will be used for pilot studies to be conducted with young clinicians, and the research plan for a study comparing tramadol to buprenorphine for the treatment of opioid withdrawal is presented. This work is highly relevant to the mission of NIH and NIDA. Recruiting and training young clinical investigators in the area of addictions are needed to advance understanding and treatment of these disorders. The applicant is well positioned to recruit young clinical investigators, has experience in successfully mentoring young researchers, and is in a strong research environment with excellent resources for mentoring and providing high quality clinical research experiences.

描述（由申请人提供）：这是一份 K24 面向患者的研究 (POR) 职业生涯中期研究员奖的申请。申请人是约翰·霍普金斯大学医学院精神病学系的医师兼研究员埃里克·斯特兰（Eric Strain）。 Strain 博士将其职业生涯奉献给了 POR，特别是与药物滥用研究和药物滥用患者治疗相关的问题。他的重点领域包括开发治疗阿片类药物和可卡因依赖的药物、与行为治疗干预相结合的药物测试、精神症状和合并症在物质使用障碍中的作用、药物滥用倾向的测试以及滥用药物的女性和男性的特殊治疗需求。该申请描述了候选人的三个直接职业目标（招募年轻医生/临床研究人员在临床成瘾研究中进行研究奖学金，通过提供各方面的直接经验，将这些临床研究人员纳入 BPRU 正在进行的和新的 POR 研究中。临床调查，并协助和指导这些临床研究人员从研究员到初级教员的过渡，鼓励每个人继续从事与成瘾相关的研究的职业道路）。此外，还描述了三个长期职业目标（培养一批具有进行成瘾相关研究专业知识的初级、中级和高级临床研究人员，作为约翰斯大学药物滥用研究的下一代研究人员霍普金斯大学，保持 BPRU 当前的研究优势，同时通过研究界的协作努力建立新的互补临床研究领域，并利用该研究团队通过协调努力推进对成瘾性疾病及其治疗的科学理解。这些目标将通过当前资助的研究工作来实现，并且简要介绍临床药理学研究以说明候选人目前资助的工作。此外，本申请的资金将用于与年轻临床医生一起进行的试点研究，并提出了一项比较曲马多和丁丙诺啡治疗阿片类药物戒断的研究计划。这项工作与 NIH 和 NIDA 的使命高度相关。需要招募和培训成瘾领域的年轻临床研究人员，以促进对这些疾病的理解和治疗。申请人有能力招募年轻的临床研究人员，具有成功指导年轻研究人员的经验，并且处于强大的研究环境中，拥有优良的指导资源和提供高质量的临床研究经验。